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- W2030367092 abstract "Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FLPioglitazone is a ligand of PPARγ nuclear receptor. Activation of PPARγ has been associated with anticancer activities in a variety of cancer cell lines through inhibition of proliferation and promotion of apoptosis. We examined the effect of pioglitazone, which is approved for the treatment of type II diabetes mellitus, on lung cancer development in carcinogen-induced non-small cell lung cancers in mice. When pioglitazone was administered beginning 8 weeks after the first dose of carcinogen treatment, pioglitazone significantly inhibited tumor load (sum of tumor volume per lung in average) by 64% (P < 0.05) in p53(wt/wt) mice and 50% (P < 0.05) in p53(wt/Ala135Val) mice in the lung adenocarcinoma model. Delayed administration of pioglitazone caused a limited (35%, P < 0.05) decrease in lung squamous cell carcinoma. Induction of apoptosis occurred in both model systems. These data show that pioglitazone significantly inhibited progression of both adenocarcinoma and SCC in the two mouse model systems.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3698. doi:10.1158/1538-7445.AM2011-3698" @default.
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- W2030367092 date "2011-04-15" @default.
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- W2030367092 title "Abstract 3698: Chemopreventive efficacy of pioglitazone on lung cancer in mice" @default.
- W2030367092 doi "https://doi.org/10.1158/1538-7445.am2011-3698" @default.
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