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- W2030367851 abstract "Objective. To investigate the effect of l-arginine on fetal growth restriction (FGR) in terms of the expression of Bcl-2 and Bax in placenta.Methods. Sixty pregnant women with FGR were randomized to receive conventional treatment alone (control group, n = 30) or in combination with l-arginine (l-arginine group, n = 30). The parameters of fetal growth and development were monitored by B-ultrasound at regular intervals. The newborn birth weight and perinatal outcomes were also documented. Placental tissue was sampled within 10 min after delivery for analysis. The expression of Bcl-2 and Bax in placental tissue was determined by immunohistochemical technique.Results. The fetal growth parameters of biparietal diameter, femur length, and abdominal circumference increased more significantly in l-arginine group than those in control group (p < 0.0l). The cure rate and birth weight in l-arginine group were higher than those in control group (73.3% vs. 43.3%, 2455.20 g vs. 2402.63 g, respectively). The incidence of small for gestational age newborns in l-arginine group was significantly lower than that in control group. Compared with l-arginine group, the Bax expression increased, but bcl-2 expression decreased in control group.Conclusions. l-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development." @default.
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- W2030367851 date "2010-11-10" @default.
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- W2030367851 title "Effect of<scp>L</scp>-arginine on the expression of Bcl-2 and Bax in the placenta of fetal growth restriction" @default.
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- W2030367851 doi "https://doi.org/10.3109/14767058.2010.531315" @default.
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