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- W2030368239 abstract "We have studied the mechanism by which β-lactam challenge leads to β-lactamase induction in Aeromonas hydrophila through transposon-insertion mutagenesis. Disruption of the dd-carboxypeptidases/endopeptidases, penicillin-binding protein 4 or BlrY leads to elevated monomer-disaccharide-pentapeptide levels in A. hydrophila peptidoglycan and concomitant overproduction of β-lactamase through activation of the BlrAB two-component regulatory system. During β-lactam challenge, monomer-disaccharide-pentapeptide levels increase proportionately with β-lactamase production and β-lactamase induction is inhibited by vancomycin, which binds muro-pentapeptides. Taken together, these data strongly suggest that the Aeromonas spp. β-lactamase regulatory sensor kinase, BlrB, responds to the concentration of monomer-disaccharide-pentapeptide in peptidoglycan." @default.
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- W2030368239 date "2010-04-29" @default.
- W2030368239 modified "2023-10-09" @default.
- W2030368239 title "Induction of -lactamase production in Aeromonas hydrophila is responsive to -lactam-mediated changes in peptidoglycan composition" @default.
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- W2030368239 doi "https://doi.org/10.1099/mic.0.035220-0" @default.
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