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• W2030371305 abstract "A strain of warfarin-resistant rats showed a lower sleeping time response to sodium pentobarbitone than the parent susceptible strain, but this difference did not appear to correlate with resistance in wild rats. Although strain differences in the extent of microsomal drug metabolism were demonstrated they were not sufficient to account for resistance. In vitro studies of warfarin metabolism showed that hydroxywarfarins, including 4'-hydroxywarfarin were synthesized. Induction by phenobarbitone led to a greater stimulation of 7-hydroxywarfarin formation compared to that of the 6-, 8-, and 4'-hydroxywarfarins. In vivo studies suggested that the rate of metabolism of warfarin by control animals was not the limiting step as far as the lethal effects of warfarin were concerned." @default.
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• W2030371305 date "1975-03-01" @default.
• W2030371305 modified "2023-10-02" @default.
• W2030371305 title "Studies of the microsomal drug metabolism system in warfarin-resistant and -susceptible rats" @default.
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• W2030371305 doi "https://doi.org/10.1016/0006-2952(75)90251-8" @default.
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