FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030373374> ?p ?o ?g. }

• W2030373374 endingPage "211" @default.
• W2030373374 startingPage "200" @default.
• W2030373374 abstract "Inflammation-related changes in the concentrations of kynurenine-pathway metabolites occur in depression secondary to medical conditions but have not been well characterized in primary bipolar disorder (BD), with contradictory results potentially attributable to the presence or absence of psychosis and/or medication effects. In contrast, reductions in hippocampal and amygdalar volume that theoretically reflect dendritic atrophy occurring in the context of a neurotoxic process are commonly reported in unmedicated BD patients. Here we tested whether the concentrations of putatively neuroprotective (kynurenic acid, KynA) and neurotoxic (3-hydroxy-kynurenine, 3HK and quinolinic acid, QA) kynurenine-pathway metabolites were altered in primary BD and whether these metabolites were associated with hippocampal and amygdalar volume. Twenty-five moderately-to-severely depressed unmedicated subjects and 38 moderately-to-severely depressed medicated subjects who met DSM-IV-TR criteria for BD, as well as 48 healthy controls (HCs) completed a structural MRI scan and provided a blood sample for kynurenine metabolite analysis, performed using high performance liquid chromatography with tandem mass spectrometry. Gray matter volumes were measured with the automated segmentation software, FreeSurfer. A putative neuroprotective index, KynA/QA, was significantly lower in the BD subjects relative to the HCs, a finding that was unrelated to current treatment with medication or a prior history of psychosis. Further, another putative neuroprotective index, KynA/3HK was positively associated with hippocampal volume in the BD group after controlling for age, sex, body mass index (BMI), and intracranial volume (ICV). Kyn/3HK was significantly associated with total amygdalar volume in the BD group, but after controlling for age, sex, BMI, but not ICV, this association was reduced to a trend. In addition, Kyn/3HK was positively associated with amygdalar volume in the HCs although the association was no longer significant after accounting for the effects of age, sex, and BMI. The results raise the possibility that BD-associated abnormalities in kynurenine metabolism may impact the structure of the hippocampus and amygdala, highlighting a pathway through which inflammation may exert neuropathological effects in the context of depression." @default.
• W2030373374 created "2016-06-24" @default.
• W2030373374 creator A5004441517 @default.
• W2030373374 creator A5010575489 @default.
• W2030373374 creator A5013531724 @default.
• W2030373374 creator A5029257842 @default.
• W2030373374 creator A5055089575 @default.
• W2030373374 creator A5072810463 @default.
• W2030373374 creator A5078488552 @default.
• W2030373374 creator A5079732394 @default.
• W2030373374 creator A5087398056 @default.
• W2030373374 date "2015-02-01" @default.
• W2030373374 modified "2023-10-18" @default.
• W2030373374 title "Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder" @default.
• W2030373374 cites W1968371119 @default.
• W2030373374 cites W1969300914 @default.
• W2030373374 cites W1971669533 @default.
• W2030373374 cites W1973172818 @default.
• W2030373374 cites W1978830885 @default.
• W2030373374 cites W1980899641 @default.
• W2030373374 cites W1981336028 @default.
• W2030373374 cites W1982021911 @default.
• W2030373374 cites W1982844998 @default.
• W2030373374 cites W1988200425 @default.
• W2030373374 cites W1990286385 @default.
• W2030373374 cites W1992517022 @default.
• W2030373374 cites W1996454121 @default.
• W2030373374 cites W1997506982 @default.
• W2030373374 cites W2004347369 @default.
• W2030373374 cites W2004822431 @default.
• W2030373374 cites W2005776786 @default.
• W2030373374 cites W2020783130 @default.
• W2030373374 cites W2022766686 @default.
• W2030373374 cites W2023281170 @default.
• W2030373374 cites W2026813655 @default.
• W2030373374 cites W2032537064 @default.
• W2030373374 cites W2036814814 @default.
• W2030373374 cites W2039232652 @default.
• W2030373374 cites W2055527753 @default.
• W2030373374 cites W2056547365 @default.
• W2030373374 cites W2057159787 @default.
• W2030373374 cites W2060050678 @default.
• W2030373374 cites W2070643074 @default.
• W2030373374 cites W2080180365 @default.
• W2030373374 cites W2089521828 @default.
• W2030373374 cites W2095920783 @default.
• W2030373374 cites W2106459619 @default.
• W2030373374 cites W2114058973 @default.
• W2030373374 cites W2119973407 @default.
• W2030373374 cites W2124979499 @default.
• W2030373374 cites W2126795224 @default.
• W2030373374 cites W2128046071 @default.
• W2030373374 cites W2128944765 @default.
• W2030373374 cites W2141195881 @default.
• W2030373374 cites W2141719314 @default.
• W2030373374 cites W2146758523 @default.
• W2030373374 cites W2163844879 @default.
• W2030373374 cites W2170298556 @default.
• W2030373374 cites W2171668977 @default.
• W2030373374 cites W2333485767 @default.
• W2030373374 cites W2460669810 @default.
• W2030373374 cites W488235 @default.
• W2030373374 doi "https://doi.org/10.1016/j.psyneuen.2014.11.015" @default.
• W2030373374 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4297593" @default.
• W2030373374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25486577" @default.
• W2030373374 hasPublicationYear "2015" @default.
• W2030373374 type Work @default.
• W2030373374 sameAs 2030373374 @default.
• W2030373374 citedByCount "100" @default.
• W2030373374 countsByYear W20303733742015 @default.
• W2030373374 countsByYear W20303733742016 @default.
• W2030373374 countsByYear W20303733742017 @default.
• W2030373374 countsByYear W20303733742018 @default.
• W2030373374 countsByYear W20303733742019 @default.
• W2030373374 countsByYear W20303733742020 @default.
• W2030373374 countsByYear W20303733742021 @default.
• W2030373374 countsByYear W20303733742022 @default.
• W2030373374 countsByYear W20303733742023 @default.
• W2030373374 crossrefType "journal-article" @default.
• W2030373374 hasAuthorship W2030373374A5004441517 @default.
• W2030373374 hasAuthorship W2030373374A5010575489 @default.
• W2030373374 hasAuthorship W2030373374A5013531724 @default.
• W2030373374 hasAuthorship W2030373374A5029257842 @default.
• W2030373374 hasAuthorship W2030373374A5055089575 @default.
• W2030373374 hasAuthorship W2030373374A5072810463 @default.
• W2030373374 hasAuthorship W2030373374A5078488552 @default.
• W2030373374 hasAuthorship W2030373374A5079732394 @default.
• W2030373374 hasAuthorship W2030373374A5087398056 @default.
• W2030373374 hasBestOaLocation W20303733742 @default.
• W2030373374 hasConcept C126322002 @default.
• W2030373374 hasConcept C134018914 @default.
• W2030373374 hasConcept C15744967 @default.
• W2030373374 hasConcept C170493617 @default.
• W2030373374 hasConcept C185592680 @default.
• W2030373374 hasConcept C25498285 @default.
• W2030373374 hasConcept C2776174506 @default.
• W2030373374 hasConcept C2776706248 @default.
• W2030373374 hasConcept C2776710720 @default.

• next