FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030374315> ?p ?o ?g. }

• W2030374315 endingPage "81" @default.
• W2030374315 startingPage "67" @default.
• W2030374315 abstract "Protein kinase C (PKC) is reported to play a role in maturation of the myeloid cell and functions of the mature neutrophil. The neutrophils in chronic myeloid leukemia (CML) exhibit defects in several functions. As a step towards understanding the role of PKC in the defects in function of the leukemic cells, this study investigates the expression of PKC isoforms, their subcellular distribution, levels and kinase activity in the normal and leukemic neutrophils. It also investigates changes in representative PKC isoforms during myeloid maturation. This study confirms the presence of PKC alpha, beta and delta and shows, for the first time, the presence of non conventional PKC isoform theta, atypical PKC isoform lambda/iota and PKC isoform mu in normal human neutrophils. In unstimulated cells all the detected PKC isoforms showed a predominantly cytosolic localisation in normal and CML neutrophils. Cytosol-membrane distribution of PKC alpha and delta were significantly altered in leukemic neutrophils as compared to normal cells. Cytosolic levels of all PKC isoforms were reduced in CML neutrophils with PKC alpha, beta, iota, theta, and mu showing a significant decrease. Cytosolic levels of PKC delta contrary to the trend observed for other PKC isoforms showed a slight increase in CML cells, while its membrane levels were significantly reduced in CML neutrophils. Total PKC kinase activity in CML neutrophil cytosol was significantly reduced, while specific kinase activity of two representative isoforms, PKC alpha and delta, from normal and CML neutrophils were similar, thereby increasing the significance of the altered levels of PKC isoforms in CML, and highlighting their role in the defects in function exhibited by the leukemic neutrophils. The levels of PKC delta and iota increased and decreased respectively as the leukemic myeloid cell matured from the blast to the neutrophil, while the levels of PKC alpha and beta were not altered. This suggests a role for PKC delta and iota in the maturation of the leukemic myeloid cell." @default.
• W2030374315 created "2016-06-24" @default.
• W2030374315 creator A5004806870 @default.
• W2030374315 creator A5042792836 @default.
• W2030374315 creator A5051407707 @default.
• W2030374315 date "2002-01-01" @default.
• W2030374315 modified "2023-09-25" @default.
• W2030374315 title "Protein kinase C isoforms in normal and leukemic neutrophils: altered levels in leukemic neutrophils and changes during myeloid maturation in chronic myeloid leukemia" @default.
• W2030374315 cites W112179857 @default.
• W2030374315 cites W1504210202 @default.
• W2030374315 cites W1573000660 @default.
• W2030374315 cites W1586099293 @default.
• W2030374315 cites W1618394762 @default.
• W2030374315 cites W173880999 @default.
• W2030374315 cites W1750774965 @default.
• W2030374315 cites W179312597 @default.
• W2030374315 cites W1844340915 @default.
• W2030374315 cites W1863130055 @default.
• W2030374315 cites W1965108107 @default.
• W2030374315 cites W1969150166 @default.
• W2030374315 cites W1971343395 @default.
• W2030374315 cites W1975524695 @default.
• W2030374315 cites W1977672499 @default.
• W2030374315 cites W1978265027 @default.
• W2030374315 cites W1982571691 @default.
• W2030374315 cites W1989911355 @default.
• W2030374315 cites W1996121260 @default.
• W2030374315 cites W2005880478 @default.
• W2030374315 cites W2015982216 @default.
• W2030374315 cites W2020646290 @default.
• W2030374315 cites W2031666929 @default.
• W2030374315 cites W2039491348 @default.
• W2030374315 cites W2039542771 @default.
• W2030374315 cites W2047975134 @default.
• W2030374315 cites W2049765895 @default.
• W2030374315 cites W2062943366 @default.
• W2030374315 cites W2069720072 @default.
• W2030374315 cites W2078448031 @default.
• W2030374315 cites W2080839196 @default.
• W2030374315 cites W2090784961 @default.
• W2030374315 cites W2095376376 @default.
• W2030374315 cites W2144420832 @default.
• W2030374315 cites W2155996040 @default.
• W2030374315 cites W2162182552 @default.
• W2030374315 cites W2411014119 @default.
• W2030374315 cites W24291559 @default.
• W2030374315 cites W4251600258 @default.
• W2030374315 cites W4256288938 @default.
• W2030374315 doi "https://doi.org/10.1016/s0145-2126(01)00098-4" @default.
• W2030374315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11734305" @default.
• W2030374315 hasPublicationYear "2002" @default.
• W2030374315 type Work @default.
• W2030374315 sameAs 2030374315 @default.
• W2030374315 citedByCount "32" @default.
• W2030374315 countsByYear W20303743152012 @default.
• W2030374315 countsByYear W20303743152013 @default.
• W2030374315 countsByYear W20303743152014 @default.
• W2030374315 countsByYear W20303743152015 @default.
• W2030374315 countsByYear W20303743152016 @default.
• W2030374315 countsByYear W20303743152018 @default.
• W2030374315 countsByYear W20303743152019 @default.
• W2030374315 countsByYear W20303743152020 @default.
• W2030374315 countsByYear W20303743152021 @default.
• W2030374315 countsByYear W20303743152022 @default.
• W2030374315 crossrefType "journal-article" @default.
• W2030374315 hasAuthorship W2030374315A5004806870 @default.
• W2030374315 hasAuthorship W2030374315A5042792836 @default.
• W2030374315 hasAuthorship W2030374315A5051407707 @default.
• W2030374315 hasConcept C104317684 @default.
• W2030374315 hasConcept C126322002 @default.
• W2030374315 hasConcept C181199279 @default.
• W2030374315 hasConcept C184235292 @default.
• W2030374315 hasConcept C195794163 @default.
• W2030374315 hasConcept C203014093 @default.
• W2030374315 hasConcept C2778729363 @default.
• W2030374315 hasConcept C2779282312 @default.
• W2030374315 hasConcept C53345823 @default.
• W2030374315 hasConcept C55493867 @default.
• W2030374315 hasConcept C71924100 @default.
• W2030374315 hasConcept C86803240 @default.
• W2030374315 hasConcept C95444343 @default.
• W2030374315 hasConcept C98539663 @default.
• W2030374315 hasConceptScore W2030374315C104317684 @default.
• W2030374315 hasConceptScore W2030374315C126322002 @default.
• W2030374315 hasConceptScore W2030374315C181199279 @default.
• W2030374315 hasConceptScore W2030374315C184235292 @default.
• W2030374315 hasConceptScore W2030374315C195794163 @default.
• W2030374315 hasConceptScore W2030374315C203014093 @default.
• W2030374315 hasConceptScore W2030374315C2778729363 @default.
• W2030374315 hasConceptScore W2030374315C2779282312 @default.
• W2030374315 hasConceptScore W2030374315C53345823 @default.
• W2030374315 hasConceptScore W2030374315C55493867 @default.
• W2030374315 hasConceptScore W2030374315C71924100 @default.
• W2030374315 hasConceptScore W2030374315C86803240 @default.
• W2030374315 hasConceptScore W2030374315C95444343 @default.
• W2030374315 hasConceptScore W2030374315C98539663 @default.
• W2030374315 hasIssue "1" @default.
• W2030374315 hasLocation W20303743151 @default.

• next