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• W2030375139 abstract "Abstract Dietary fiber has important roles in lowering blood lipids and, at least for diabetic people, in controlling blood glucose. Unfortunately, mechanisms by which fiber exerts these important effects are poorly understood. The result is that one has little basis for rating the metabolic potency of fibers from their chemical or physical properties and for making specific and quantitative recommendations about fiber intakes for people. Ultimately, one needs to develop and test mechanistic models that predict how various changes in dietary fiber will affect the rate and magnitude of changes in blood lipids. The present study represents an early step toward that goal. A semi-purified fiber supplement (Fiber Excel) was added daily to the self-selected diets of a small group of noninsulin dependent diabetic and nondiabetic subjects for two weeks, and fasting bloods were taken prior to the supplement, after 1 and 2 weeks of fiber supplementation, and 1 week later. The extra fiber elicited few complaints of abdominal distress. Plasma glucose was depressed after 1 week in diabetic subjects while triglycerides were depressed after 1 and 2 weeks in nondiabetics. Total cholesterol tended to decrease (P > 0.05) among diabetic subjects, and the decrease was statistically significant in the high-density lipoprotein fraction in both groups. None of the parameters affected by extra fiber changed significantly within 1 week of its withdrawal. It appears that the time course of effects of adding or removing extra fiber from the diet can be observed and that these effects may persist for more than 1 week." @default.
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• W2030375139 date "1992-07-01" @default.
• W2030375139 modified "2023-09-25" @default.
• W2030375139 title "Perturbations of blood chemistry and after the short-term feeding of a fiber supplement in noninsulin dependent diabetic and nondiabetic subjects" @default.
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• W2030375139 doi "https://doi.org/10.1016/0955-2863(92)90027-g" @default.
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