FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030376051> ?p ?o ?g. }

• W2030376051 endingPage "294" @default.
• W2030376051 startingPage "286" @default.
• W2030376051 abstract "This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.” The body is colonized by highly complex and genetically diverse communities of microbes, the majority of which reside within the intestines in largely stable but dynamically interactive climax communities. These microbes, referred to as the microbiota, have many functions that enhance the health of the host, and it is now recognized that the microbiota influence both mucosal and systemic immunity. The studies outlined in this review demonstrate that the microbiota are also involved in stressor-induced immunomodulation. Exposure to different types of stressors, including both physical and psychological stressors, changes the composition of the intestinal microbiota. The altered profile increases susceptibility to an enteric pathogen, i.e., Citrobacter rodentium, upon oral challenge, but is also associated with stressor-induced increases in innate immune activity. Studies using germfree mice, as well as antibiotic-treated mice, provide further evidence that the microbiota contribute to stressor-induced immunomodulation; stressor-induced increases in splenic macrophage microbicidal activity fail to occur in mice with no, or reduced, intestinal microbiota. While the mechanisms by which microbiota can impact mucosal immunity have been studied, how the microbiota impact systemic immune responses is not clear. A mechanism is proposed in which stressor-induced degranulation of mucosal mast cells increases the permeability of the intestines. This increased permeability would allow intact bacteria and/or bacterial products (like peptidoglycan) to translocate from the lumen of the intestines to the interior of the body, where they directly, or indirectly, prime the innate immune system for enhanced reactivity to antigenic stimulation." @default.
• W2030376051 created "2016-06-24" @default.
• W2030376051 creator A5034366268 @default.
• W2030376051 date "2012-08-01" @default.
• W2030376051 modified "2023-10-15" @default.
• W2030376051 title "The contributing role of the intestinal microbiota in stressor-induced increases in susceptibility to enteric infection and systemic immunomodulation" @default.
• W2030376051 cites W1501872728 @default.
• W2030376051 cites W1515577367 @default.
• W2030376051 cites W1531920134 @default.
• W2030376051 cites W1660862525 @default.
• W2030376051 cites W1878109538 @default.
• W2030376051 cites W1909506909 @default.
• W2030376051 cites W191068927 @default.
• W2030376051 cites W1952460190 @default.
• W2030376051 cites W1967821667 @default.
• W2030376051 cites W1968105193 @default.
• W2030376051 cites W1971415551 @default.
• W2030376051 cites W1971740873 @default.
• W2030376051 cites W1979500720 @default.
• W2030376051 cites W1985240984 @default.
• W2030376051 cites W1987985249 @default.
• W2030376051 cites W1989128330 @default.
• W2030376051 cites W1989616225 @default.
• W2030376051 cites W1993239608 @default.
• W2030376051 cites W1993678078 @default.
• W2030376051 cites W1996834360 @default.
• W2030376051 cites W2001982841 @default.
• W2030376051 cites W2004192158 @default.
• W2030376051 cites W2004665610 @default.
• W2030376051 cites W2006485530 @default.
• W2030376051 cites W2011010821 @default.
• W2030376051 cites W2016955007 @default.
• W2030376051 cites W2017968071 @default.
• W2030376051 cites W2019573101 @default.
• W2030376051 cites W2021700795 @default.
• W2030376051 cites W2022187324 @default.
• W2030376051 cites W2025114863 @default.
• W2030376051 cites W2026074634 @default.
• W2030376051 cites W2026429915 @default.
• W2030376051 cites W2027241596 @default.
• W2030376051 cites W2031967942 @default.
• W2030376051 cites W2032605955 @default.
• W2030376051 cites W2035048561 @default.
• W2030376051 cites W2038217946 @default.
• W2030376051 cites W2038270610 @default.
• W2030376051 cites W2039079048 @default.
• W2030376051 cites W2039912040 @default.
• W2030376051 cites W2040951062 @default.
• W2030376051 cites W2041380340 @default.
• W2030376051 cites W2045119680 @default.
• W2030376051 cites W2047570180 @default.
• W2030376051 cites W2048093113 @default.
• W2030376051 cites W2052717138 @default.
• W2030376051 cites W2056550977 @default.
• W2030376051 cites W2064305818 @default.
• W2030376051 cites W2065231269 @default.
• W2030376051 cites W2066176460 @default.
• W2030376051 cites W2069007145 @default.
• W2030376051 cites W2070413937 @default.
• W2030376051 cites W2073112141 @default.
• W2030376051 cites W2073366531 @default.
• W2030376051 cites W2073976389 @default.
• W2030376051 cites W2075416068 @default.
• W2030376051 cites W2079131687 @default.
• W2030376051 cites W2082347869 @default.
• W2030376051 cites W2084120324 @default.
• W2030376051 cites W2084407626 @default.
• W2030376051 cites W2089612575 @default.
• W2030376051 cites W2092790304 @default.
• W2030376051 cites W2094422818 @default.
• W2030376051 cites W2095345518 @default.
• W2030376051 cites W2095713067 @default.
• W2030376051 cites W2096129454 @default.
• W2030376051 cites W2097118860 @default.
• W2030376051 cites W2097875133 @default.
• W2030376051 cites W2099119185 @default.
• W2030376051 cites W2106715395 @default.
• W2030376051 cites W2107155323 @default.
• W2030376051 cites W2110235509 @default.
• W2030376051 cites W2114229205 @default.
• W2030376051 cites W2115090185 @default.
• W2030376051 cites W2117727476 @default.
• W2030376051 cites W2117736614 @default.
• W2030376051 cites W2119015087 @default.
• W2030376051 cites W2121187468 @default.
• W2030376051 cites W2122309805 @default.
• W2030376051 cites W2127143533 @default.
• W2030376051 cites W2133353372 @default.
• W2030376051 cites W2134928825 @default.
• W2030376051 cites W2135387962 @default.
• W2030376051 cites W2135997523 @default.
• W2030376051 cites W2139240706 @default.
• W2030376051 cites W2141354880 @default.
• W2030376051 cites W2143862999 @default.
• W2030376051 cites W2146548337 @default.
• W2030376051 cites W2149573313 @default.
• W2030376051 cites W2154688936 @default.
• W2030376051 cites W2155897723 @default.

• next