FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030376227> ?p ?o ?g. }

• W2030376227 endingPage "224" @default.
• W2030376227 startingPage "220" @default.
• W2030376227 abstract "The biochemical or biophysical characterization of a papain-like cysteine protease in HEV ORF1-encoded polyprotein still remains elusive. Very recently, we have demonstrated the indispensability of ORF1 protease-domain cysteines and histidines in HEV replication, ex vivo (Parvez, 2013). In this report, the polyprotein partial sequences of HEV strains and genetically-related RNA viruses were analyzed, in silico. Employing the consensus-prediction results of RUBV-p(150) protease as structural-template, a 3D model of HEV-protease was deduced. Similar to RUBV-p(150), a 'papain-like β-barrel fold' structurally confirmed the classification of HEV-protease. Further, we recognized a catalytic 'Cys434-His443' dyad homologue of RUBV-p(150) (Cys1152-His1273) and FMDV-L(pro) (Cys51-His148) in line with our previous mutational analysis that showed essentiality of 'His443' but not 'His590' in HEV viability. Moreover, a RUBV 'Zn(2+) binding motif' (Cys1167-Cys1175-Cys1178-Cys1225-Cys1227) equivalent of HEV was identified as 'Cys457-His458-Cys459 and Cys481-Cys483' residues within the 'β-barrel fold'. Notably, unlike RUBV, 'His458' also clustered therein, that was in conformity with the consensus cysteine protease 'Zn(2+)-binding motif'. By homology, we also proposed an overlapping 'Ca(2+)-binding site' 'D-X-[DNS]-[ILVFYW]-[DEN]-G-[GP]-XX-DE' signature, and a 'proline-rich motif' interacting 'tryptophan (W437-W472)' module in the modeled structure. Our analysis of the predicted model therefore, warrants critical roles of the 'catalytic dyad' and 'divalent metal-binding motifs' in HEV protease structural-integrity, ORF1 self-processing, and RNA replication. This however, needs further experimental validations." @default.
• W2030376227 created "2016-06-24" @default.
• W2030376227 creator A5030443288 @default.
• W2030376227 creator A5085061081 @default.
• W2030376227 date "2014-01-01" @default.
• W2030376227 modified "2023-09-27" @default.
• W2030376227 title "Molecular modeling and analysis of hepatitis E virus (HEV) papain-like cysteine protease" @default.
• W2030376227 cites W1516528212 @default.
• W2030376227 cites W1524435320 @default.
• W2030376227 cites W1820059629 @default.
• W2030376227 cites W1964519906 @default.
• W2030376227 cites W1966720890 @default.
• W2030376227 cites W1972050993 @default.
• W2030376227 cites W1977655940 @default.
• W2030376227 cites W1981123437 @default.
• W2030376227 cites W1987962702 @default.
• W2030376227 cites W2001170827 @default.
• W2030376227 cites W2005299872 @default.
• W2030376227 cites W2015338902 @default.
• W2030376227 cites W2023123082 @default.
• W2030376227 cites W2029274089 @default.
• W2030376227 cites W2033125798 @default.
• W2030376227 cites W2040463885 @default.
• W2030376227 cites W2050951470 @default.
• W2030376227 cites W2076868063 @default.
• W2030376227 cites W2083736670 @default.
• W2030376227 cites W2084208175 @default.
• W2030376227 cites W2092417953 @default.
• W2030376227 cites W2097797047 @default.
• W2030376227 cites W2110863368 @default.
• W2030376227 cites W2111627216 @default.
• W2030376227 cites W2113638843 @default.
• W2030376227 cites W2121313939 @default.
• W2030376227 cites W2121361185 @default.
• W2030376227 cites W2122994445 @default.
• W2030376227 cites W2135469053 @default.
• W2030376227 cites W2149301799 @default.
• W2030376227 cites W2164482939 @default.
• W2030376227 cites W2188013053 @default.
• W2030376227 doi "https://doi.org/10.1016/j.virusres.2013.11.016" @default.
• W2030376227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7114377" @default.
• W2030376227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24321124" @default.
• W2030376227 hasPublicationYear "2014" @default.
• W2030376227 type Work @default.
• W2030376227 sameAs 2030376227 @default.
• W2030376227 citedByCount "24" @default.
• W2030376227 countsByYear W20303762272014 @default.
• W2030376227 countsByYear W20303762272015 @default.
• W2030376227 countsByYear W20303762272016 @default.
• W2030376227 countsByYear W20303762272017 @default.
• W2030376227 countsByYear W20303762272018 @default.
• W2030376227 countsByYear W20303762272019 @default.
• W2030376227 countsByYear W20303762272020 @default.
• W2030376227 countsByYear W20303762272021 @default.
• W2030376227 countsByYear W20303762272022 @default.
• W2030376227 countsByYear W20303762272023 @default.
• W2030376227 crossrefType "journal-article" @default.
• W2030376227 hasAuthorship W2030376227A5030443288 @default.
• W2030376227 hasAuthorship W2030376227A5085061081 @default.
• W2030376227 hasBestOaLocation W20303762271 @default.
• W2030376227 hasConcept C104317684 @default.
• W2030376227 hasConcept C132379496 @default.
• W2030376227 hasConcept C153911025 @default.
• W2030376227 hasConcept C159047783 @default.
• W2030376227 hasConcept C169627665 @default.
• W2030376227 hasConcept C181199279 @default.
• W2030376227 hasConcept C24284526 @default.
• W2030376227 hasConcept C2775905019 @default.
• W2030376227 hasConcept C2776714187 @default.
• W2030376227 hasConcept C2777283782 @default.
• W2030376227 hasConcept C2779201268 @default.
• W2030376227 hasConcept C2779832904 @default.
• W2030376227 hasConcept C55493867 @default.
• W2030376227 hasConcept C86339819 @default.
• W2030376227 hasConcept C86803240 @default.
• W2030376227 hasConceptScore W2030376227C104317684 @default.
• W2030376227 hasConceptScore W2030376227C132379496 @default.
• W2030376227 hasConceptScore W2030376227C153911025 @default.
• W2030376227 hasConceptScore W2030376227C159047783 @default.
• W2030376227 hasConceptScore W2030376227C169627665 @default.
• W2030376227 hasConceptScore W2030376227C181199279 @default.
• W2030376227 hasConceptScore W2030376227C24284526 @default.
• W2030376227 hasConceptScore W2030376227C2775905019 @default.
• W2030376227 hasConceptScore W2030376227C2776714187 @default.
• W2030376227 hasConceptScore W2030376227C2777283782 @default.
• W2030376227 hasConceptScore W2030376227C2779201268 @default.
• W2030376227 hasConceptScore W2030376227C2779832904 @default.
• W2030376227 hasConceptScore W2030376227C55493867 @default.
• W2030376227 hasConceptScore W2030376227C86339819 @default.
• W2030376227 hasConceptScore W2030376227C86803240 @default.
• W2030376227 hasLocation W20303762271 @default.
• W2030376227 hasLocation W20303762272 @default.
• W2030376227 hasLocation W20303762273 @default.
• W2030376227 hasLocation W20303762274 @default.
• W2030376227 hasOpenAccess W2030376227 @default.
• W2030376227 hasPrimaryLocation W20303762271 @default.
• W2030376227 hasRelatedWork W1966846792 @default.
• W2030376227 hasRelatedWork W2030376227 @default.

• next