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- W2030382441 abstract "Alternative splicing is an important mechanism mediating the function of genes in multicellular organisms. Recently, we discovered a new splicing-junction wobble mechanism that generates subtle alterations in mRNA by randomly selecting tandem 5′ and 3′ splicing-junction sites. Here we developed a sensitive approach to identify such splicing-junction wobble isoforms using polymerase chain reaction amplification with fluorescence-labeled primers encompassing the wobble-splicing boundary and capillary electrophoresis. Using the ING4 wobble isoforms as an example, we demonstrated that capillary electrophoresis can precisely separate DNA fragments with a small difference in size (< 3 nt) and can be used to quantify the expression ratio, which thus measures the distribution of each splicing-junction wobble isoform in tissues. Based on our analyses of several genes, the relative ratio of each wobble-splicing isoform tends to be constant among various tissues. The occasional observed tissue heterogeneity of wobble-splicing transcripts can be generated only by genomic single-nucleotide polymorphisms around the splicing junction." @default.
- W2030382441 created "2016-06-24" @default.
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- W2030382441 date "2006-12-01" @default.
- W2030382441 modified "2023-09-28" @default.
- W2030382441 title "Quantitative analysis of wobble splicing indicates that it is not tissue specific" @default.
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- W2030382441 doi "https://doi.org/10.1016/j.ygeno.2006.07.004" @default.
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