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- W2030385648 abstract "The early action of α-amanitin was studied by electron microscopy on liver cells of normal rats or after starvation for 2 days and refeeding. The earliest changes visualized by means of the EDTA staining method occurred in nuclei of hepatocytes at the surface of the dense chromatin. Thirty minutes after the action of the drug, the number of RNP-containing perichromatin fibrils decreased in some cells, and after 1 h, they were very strongly reduced throughout the liver tissue. Fragmentation of nucleoli and segregation of their components occurred, large aggregates of interchromatin granules appeared and occasionally the number of perichromatin granules was increased. Furthermore, α-amanitin blocked the reappearance of perichromatin fibrils in liver cells from animals which were starved for 2 days and refed for 1 h. These fine structural changes are in good agreement with biochemical findings concerning the inhibition of extranucleolar RNA polymerase by α-amanitin, perichromatin fibrils being considered as the morphological expression of rapidly synthesized extranucleolar RNA." @default.
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- W2030385648 date "1971-12-01" @default.
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- W2030385648 title "Early action of ?-amanitin on extranucleolar ribonucleoproteins, as revealed by electron microscopic observation" @default.
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- W2030385648 doi "https://doi.org/10.1016/0014-4827(71)90240-0" @default.
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