FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030394543> ?p ?o ?g. }

• W2030394543 endingPage "304" @default.
• W2030394543 startingPage "296" @default.
• W2030394543 abstract "Abstract Human peripheral blood contains two major dendritic cell (DC) populations, namely CD11c–CD123+ plasmacytoid DCs (PDCs) and CD11c+CD123– myeloid DCs (MDCs). Although the activation of these DC types by various TLR ligands has been relatively well-characterized, less is known about the ability of whole live bacteria to induce PDC and MDC activation. In the present report, we have compared the activation of human PDCs and MDCs in response to major human bacterial pathogen Streptococcus pyogenes (group A streptococci) and influenza A virus. S. pyogenes stimulation resulted in the maturation of both DC types, as evidenced by enhanced expression of costimulatory molecules and production of proinflammatory cytokines and chemokines. Furthermore, S. pyogenes-stimulated PDCs and MDCs activated naïve CD4+ T cells and enhanced their Th1 cytokine production. Influenza A virus infection induced rapid PDC activation, whereas MDCs were extremely sensitive to influenza A virus-induced cell death. The most significant differences between DC types were seen in the production of IL-10 and IL-12, which were only produced by S. pyogenes-stimulated MDCs. Although S. pyogenes was able to induce PDC activation, only influenza A virus infection resulted in detectable IFN-α production. Our results show that depending on the infecting microbe, the functions of PDCs and MDCs may be partially overlapping, suggesting a considerable flexibility of the human DC system." @default.
• W2030394543 created "2016-06-24" @default.
• W2030394543 creator A5007995979 @default.
• W2030394543 creator A5054688234 @default.
• W2030394543 date "2007-10-26" @default.
• W2030394543 modified "2023-10-16" @default.
• W2030394543 title "<i>Streptococcus pyogenes</i>activates human plasmacytoid and myeloid dendritic cells" @default.
• W2030394543 cites W111924924 @default.
• W2030394543 cites W1511825494 @default.
• W2030394543 cites W1536488163 @default.
• W2030394543 cites W1605033827 @default.
• W2030394543 cites W1637811627 @default.
• W2030394543 cites W1653683821 @default.
• W2030394543 cites W1667435701 @default.
• W2030394543 cites W1878018231 @default.
• W2030394543 cites W1896084611 @default.
• W2030394543 cites W1945216762 @default.
• W2030394543 cites W1968536379 @default.
• W2030394543 cites W1969430178 @default.
• W2030394543 cites W1970573066 @default.
• W2030394543 cites W1975632752 @default.
• W2030394543 cites W1981746803 @default.
• W2030394543 cites W1990451575 @default.
• W2030394543 cites W1999070120 @default.
• W2030394543 cites W2003634035 @default.
• W2030394543 cites W2006772331 @default.
• W2030394543 cites W2009392385 @default.
• W2030394543 cites W2023397244 @default.
• W2030394543 cites W2026018003 @default.
• W2030394543 cites W2041170922 @default.
• W2030394543 cites W2042402786 @default.
• W2030394543 cites W2043667001 @default.
• W2030394543 cites W2057127718 @default.
• W2030394543 cites W2062350041 @default.
• W2030394543 cites W2063435821 @default.
• W2030394543 cites W2099697271 @default.
• W2030394543 cites W2109381735 @default.
• W2030394543 cites W2111220263 @default.
• W2030394543 cites W2112830536 @default.
• W2030394543 cites W2114913546 @default.
• W2030394543 cites W2116633412 @default.
• W2030394543 cites W2118537722 @default.
• W2030394543 cites W2120963279 @default.
• W2030394543 cites W2122643628 @default.
• W2030394543 cites W2123786729 @default.
• W2030394543 cites W2130255026 @default.
• W2030394543 cites W2131759804 @default.
• W2030394543 cites W2148036915 @default.
• W2030394543 cites W2151777859 @default.
• W2030394543 cites W2155926864 @default.
• W2030394543 cites W2160739580 @default.
• W2030394543 cites W2161880384 @default.
• W2030394543 cites W2167276755 @default.
• W2030394543 doi "https://doi.org/10.1189/jlb.0707457" @default.
• W2030394543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17965337" @default.
• W2030394543 hasPublicationYear "2007" @default.
• W2030394543 type Work @default.
• W2030394543 sameAs 2030394543 @default.
• W2030394543 citedByCount "30" @default.
• W2030394543 countsByYear W20303945432012 @default.
• W2030394543 countsByYear W20303945432013 @default.
• W2030394543 countsByYear W20303945432014 @default.
• W2030394543 countsByYear W20303945432015 @default.
• W2030394543 countsByYear W20303945432016 @default.
• W2030394543 countsByYear W20303945432018 @default.
• W2030394543 countsByYear W20303945432019 @default.
• W2030394543 countsByYear W20303945432020 @default.
• W2030394543 countsByYear W20303945432021 @default.
• W2030394543 countsByYear W20303945432022 @default.
• W2030394543 crossrefType "journal-article" @default.
• W2030394543 hasAuthorship W2030394543A5007995979 @default.
• W2030394543 hasAuthorship W2030394543A5054688234 @default.
• W2030394543 hasBestOaLocation W20303945431 @default.
• W2030394543 hasConcept C104317684 @default.
• W2030394543 hasConcept C127716648 @default.
• W2030394543 hasConcept C13373296 @default.
• W2030394543 hasConcept C164027704 @default.
• W2030394543 hasConcept C203014093 @default.
• W2030394543 hasConcept C2522874641 @default.
• W2030394543 hasConcept C2776051438 @default.
• W2030394543 hasConcept C2776914184 @default.
• W2030394543 hasConcept C2778170410 @default.
• W2030394543 hasConcept C2778690821 @default.
• W2030394543 hasConcept C2779282312 @default.
• W2030394543 hasConcept C2779306812 @default.
• W2030394543 hasConcept C2779489039 @default.
• W2030394543 hasConcept C2779919695 @default.
• W2030394543 hasConcept C523546767 @default.
• W2030394543 hasConcept C54355233 @default.
• W2030394543 hasConcept C55493867 @default.
• W2030394543 hasConcept C86803240 @default.
• W2030394543 hasConcept C8891405 @default.
• W2030394543 hasConcept C89423630 @default.
• W2030394543 hasConceptScore W2030394543C104317684 @default.
• W2030394543 hasConceptScore W2030394543C127716648 @default.
• W2030394543 hasConceptScore W2030394543C13373296 @default.
• W2030394543 hasConceptScore W2030394543C164027704 @default.
• W2030394543 hasConceptScore W2030394543C203014093 @default.

• next