FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030396261> ?p ?o ?g. }

• W2030396261 endingPage "227" @default.
• W2030396261 startingPage "220" @default.
• W2030396261 abstract "The anterior portion of the neonatal telencephalic subventricular zone (SVZa) contains proliferating cells that generate an immense number of neurons destined to become the granule and periglomerular cells of the olfactory bulb. In contrast to other immature neurons in the central nervous system, cells arising in the SVZa maintain the ability to divide as they traverse the rostral migratory stream to their final destinations despite expressing an antigenic marker of differentiated neurons (Menezes et al. [1995] Molec. Cell. Neurosci. 6:496–508). Because of their considerable proliferative capacities and unusual mitotic behavior, we decided to determine the cell cycle length of proliferating cells within the SVZa and within the migratory pathway used by SVZa-derived cells. Following the methodology of Nowakowski et al. [1989](J. Neurocytol. 18:311–318), postnatal day 2 rat pups were exposed to 5'-bromo-2'deoxyuridine (BrdU) for increasing periods of time before perfusion. By plotting the percentage of nuclei undergoing DNA synthesis in the SVZa at each time versus the BrdU labeling interval, we determined that approximately 15% of the SVZa population is actively dividing and that these cells have a cycle length of approximately 14 hr, significantly less than the 18.6 hr determined to be the cycle length of dividing cells in more posterior, glia-generating regions of the subventricular zone (Thomaidou et al. [1997] J. Neurosci. 17:1075–1085). The cycle length of cells dividing in the mid portion of the rostral migratory stream, however, is considerably longer: 17.3 hr. This may reflect the need for these cells to coordinate the processes of migration and division. Our studies also suggest that there may be regional differences in the types of descendants produced by the proliferating cells. Retroviral lineage tracing studies showed that those cells that divide within the rostral migratory stream, like proliferating cells within the SVZa, make cells destined for the olfactory bulb. Unlike the progenitors that divide within the SVZa and generate more granule cells than periglomerular cells, the proliferating cells within the migratory pathway generate more periglomerular cells than granule cells. Collectively the proliferating cells of the SVZa and migratory pathway produce a large number of olfactory bulb interneurons. Our work suggests that this may be achieved in part by the relatively rapid divisions of progenitor cells within the SVZa and in part by the ongoing division of migrating cells en route to the olfactory bulb. Dev. Dyn. 1998;213:220–227. © 1998 Wiley-Liss, Inc." @default.
• W2030396261 created "2016-06-24" @default.
• W2030396261 creator A5010504185 @default.
• W2030396261 creator A5012025063 @default.
• W2030396261 date "1998-10-01" @default.
• W2030396261 modified "2023-10-18" @default.
• W2030396261 title "Cell cycle length of olfactory bulb neuronal progenitors in the rostral migratory stream" @default.
• W2030396261 cites W1506357334 @default.
• W2030396261 cites W1671067214 @default.
• W2030396261 cites W1775329494 @default.
• W2030396261 cites W1978852687 @default.
• W2030396261 cites W1991248474 @default.
• W2030396261 cites W1997652652 @default.
• W2030396261 cites W2003735806 @default.
• W2030396261 cites W2023291891 @default.
• W2030396261 cites W2030508161 @default.
• W2030396261 cites W2035250926 @default.
• W2030396261 cites W2062581483 @default.
• W2030396261 cites W2062901218 @default.
• W2030396261 cites W2072673889 @default.
• W2030396261 cites W2083845804 @default.
• W2030396261 cites W2084761937 @default.
• W2030396261 cites W2132691381 @default.
• W2030396261 cites W2139450672 @default.
• W2030396261 cites W2189027870 @default.
• W2030396261 cites W4245963666 @default.
• W2030396261 cites W61334266 @default.
• W2030396261 doi "https://doi.org/10.1002/(sici)1097-0177(199810)213:2<220::aid-aja7>3.0.co;2-i" @default.
• W2030396261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9786422" @default.
• W2030396261 hasPublicationYear "1998" @default.
• W2030396261 type Work @default.
• W2030396261 sameAs 2030396261 @default.
• W2030396261 citedByCount "86" @default.
• W2030396261 countsByYear W20303962612012 @default.
• W2030396261 countsByYear W20303962612013 @default.
• W2030396261 countsByYear W20303962612014 @default.
• W2030396261 countsByYear W20303962612015 @default.
• W2030396261 countsByYear W20303962612016 @default.
• W2030396261 countsByYear W20303962612019 @default.
• W2030396261 countsByYear W20303962612020 @default.
• W2030396261 countsByYear W20303962612021 @default.
• W2030396261 crossrefType "journal-article" @default.
• W2030396261 hasAuthorship W2030396261A5010504185 @default.
• W2030396261 hasAuthorship W2030396261A5012025063 @default.
• W2030396261 hasBestOaLocation W20303962611 @default.
• W2030396261 hasConcept C105702510 @default.
• W2030396261 hasConcept C144024400 @default.
• W2030396261 hasConcept C1491633281 @default.
• W2030396261 hasConcept C149923435 @default.
• W2030396261 hasConcept C169760540 @default.
• W2030396261 hasConcept C201750760 @default.
• W2030396261 hasConcept C202474031 @default.
• W2030396261 hasConcept C2777542384 @default.
• W2030396261 hasConcept C2780496858 @default.
• W2030396261 hasConcept C28328180 @default.
• W2030396261 hasConcept C2908647359 @default.
• W2030396261 hasConcept C29537977 @default.
• W2030396261 hasConcept C4746552 @default.
• W2030396261 hasConcept C529278444 @default.
• W2030396261 hasConcept C54355233 @default.
• W2030396261 hasConcept C86803240 @default.
• W2030396261 hasConcept C93304396 @default.
• W2030396261 hasConcept C95444343 @default.
• W2030396261 hasConceptScore W2030396261C105702510 @default.
• W2030396261 hasConceptScore W2030396261C144024400 @default.
• W2030396261 hasConceptScore W2030396261C1491633281 @default.
• W2030396261 hasConceptScore W2030396261C149923435 @default.
• W2030396261 hasConceptScore W2030396261C169760540 @default.
• W2030396261 hasConceptScore W2030396261C201750760 @default.
• W2030396261 hasConceptScore W2030396261C202474031 @default.
• W2030396261 hasConceptScore W2030396261C2777542384 @default.
• W2030396261 hasConceptScore W2030396261C2780496858 @default.
• W2030396261 hasConceptScore W2030396261C28328180 @default.
• W2030396261 hasConceptScore W2030396261C2908647359 @default.
• W2030396261 hasConceptScore W2030396261C29537977 @default.
• W2030396261 hasConceptScore W2030396261C4746552 @default.
• W2030396261 hasConceptScore W2030396261C529278444 @default.
• W2030396261 hasConceptScore W2030396261C54355233 @default.
• W2030396261 hasConceptScore W2030396261C86803240 @default.
• W2030396261 hasConceptScore W2030396261C93304396 @default.
• W2030396261 hasConceptScore W2030396261C95444343 @default.
• W2030396261 hasIssue "2" @default.
• W2030396261 hasLocation W20303962611 @default.
• W2030396261 hasLocation W20303962612 @default.
• W2030396261 hasOpenAccess W2030396261 @default.
• W2030396261 hasPrimaryLocation W20303962611 @default.
• W2030396261 hasRelatedWork W1502968562 @default.
• W2030396261 hasRelatedWork W2012253237 @default.
• W2030396261 hasRelatedWork W2014848677 @default.
• W2030396261 hasRelatedWork W2021926559 @default.
• W2030396261 hasRelatedWork W2114352534 @default.
• W2030396261 hasRelatedWork W2132563458 @default.
• W2030396261 hasRelatedWork W2135046848 @default.
• W2030396261 hasRelatedWork W2155076048 @default.
• W2030396261 hasRelatedWork W2338787884 @default.
• W2030396261 hasRelatedWork W2594731997 @default.
• W2030396261 hasVolume "213" @default.
• W2030396261 isParatext "false" @default.

• next