FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030400577> ?p ?o ?g. }

• W2030400577 abstract "Background. Stroke in young is the leading cause of morbidity and mortality in the Indian subcontinent with a reported incidence of 15–30% of all stroke patients. The mechanisms for stroke in the young may include unconventional risk factors such as infections. Causative role of C. pneumoniae infection in patients with acute ischemic stroke (AIS) remains unresolved till date, although the link between C. pneumoniae and cerebrovascular disease has been investigated in many studies. This study examined the upregulation of IL-6 after acute cerebral ischemia and correlated the same with the C. pneumoniae antibody titres (IgG, IgA, and IgM). Methods. We studied blood samples from eighty (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>80</mml:mn></mml:math>) acute stroke patients and healthy age- and sex-matched controls. Venous blood samples were drawn within one week from the onset of stroke. Detection of IgA, IgG, and IgM antibodies to C. pneumoniae was done with a validated microimmunofluorescence (MIF) technique from 5 mL of serum in all subjects. Interleukin-6 was estimated with sandwich ELISA method. Results. The IL-6 levels were elevated in patients with a mean 28.9 ± 8.6 pg/mL as compared to 4.7 + 1.8 pg/mL in healthy age-matched controls (95% CI: 37.7 to 78.4; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.004</mml:mn></mml:math>). On correlation of IL-6 to stroke severity, it was found that 30 patients with NIHSS between 0 and 15 had mean IL-6 of 24.6 pg/mL and 50 patients had NIHSS of 18.8 (severely affected) with a mean IL-6 of 43.8 pg/mL. On multivariate analysis after adjusting for sex, hypertension, diabetes mellitus, smoking, and alcohol, the IgA seropositivity yielded an adjusted OR for stroke (4.72; 95% CI: 1.61, 13.83; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.005</mml:mn></mml:math>), while IgG seropositivity did not show a statistically significant result. We also observed that 81% of cases were seropositive for IgA versus 32% of controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.003</mml:mn></mml:math>) followed by IgG, as 52.7% of cases were seropositive versus 17.3% of controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.05</mml:mn></mml:math>). Multiple regression analysis was done with IL-6 as dependent variable to antibody with IL-6 as dependent variable to Cp-IgA, Cp-IgG, and IgM with 10.4% change in the IL-6 titres showing statistical significant result <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>F</mml:mi><mml:mn>(4,115)</mml:mn></mml:math> = 3.32, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.01</mml:mn></mml:math>. Conclusions. IL-6 has important role after acute ischemic stroke and is correlated with stroke severity and may correlate to acute or chronic infectious states with C. pneumonia." @default.
• W2030400577 created "2016-06-24" @default.
• W2030400577 creator A5005633411 @default.
• W2030400577 creator A5014947216 @default.
• W2030400577 creator A5015474583 @default.
• W2030400577 creator A5022843473 @default.
• W2030400577 creator A5046417463 @default.
• W2030400577 creator A5090097466 @default.
• W2030400577 creator A5091293579 @default.
• W2030400577 date "2014-07-20" @default.
• W2030400577 modified "2023-10-17" @default.
• W2030400577 title "Role of Interleukin-6 Correlated to C. pneumoniae Infection as a Biomarker for Prediction of Stroke Severity in Young Patients with Acute Ischemic Stroke" @default.
• W2030400577 cites W1556471290 @default.
• W2030400577 cites W1910798354 @default.
• W2030400577 cites W1969182835 @default.
• W2030400577 cites W1981657664 @default.
• W2030400577 cites W1982926065 @default.
• W2030400577 cites W1987764662 @default.
• W2030400577 cites W2000225733 @default.
• W2030400577 cites W2006205771 @default.
• W2030400577 cites W2013504879 @default.
• W2030400577 cites W2014749957 @default.
• W2030400577 cites W2015397316 @default.
• W2030400577 cites W2016962058 @default.
• W2030400577 cites W2040910740 @default.
• W2030400577 cites W2042313213 @default.
• W2030400577 cites W2043658034 @default.
• W2030400577 cites W2046738189 @default.
• W2030400577 cites W2048350854 @default.
• W2030400577 cites W2058586534 @default.
• W2030400577 cites W2062777958 @default.
• W2030400577 cites W2077611568 @default.
• W2030400577 cites W2084856456 @default.
• W2030400577 cites W2084977288 @default.
• W2030400577 cites W2088475856 @default.
• W2030400577 cites W2089263724 @default.
• W2030400577 cites W2090238119 @default.
• W2030400577 cites W2091422051 @default.
• W2030400577 cites W2094941678 @default.
• W2030400577 cites W2107001382 @default.
• W2030400577 cites W2119154276 @default.
• W2030400577 cites W2128456788 @default.
• W2030400577 cites W2132401640 @default.
• W2030400577 cites W2135889423 @default.
• W2030400577 cites W2141674983 @default.
• W2030400577 cites W2141683458 @default.
• W2030400577 cites W2146336916 @default.
• W2030400577 cites W2155551314 @default.
• W2030400577 cites W2163609683 @default.
• W2030400577 cites W2165885906 @default.
• W2030400577 cites W4232696887 @default.
• W2030400577 cites W4243529104 @default.
• W2030400577 doi "https://doi.org/10.1155/2014/649106" @default.
• W2030400577 hasPublicationYear "2014" @default.
• W2030400577 type Work @default.
• W2030400577 sameAs 2030400577 @default.
• W2030400577 citedByCount "1" @default.
• W2030400577 countsByYear W20304005772020 @default.
• W2030400577 crossrefType "journal-article" @default.
• W2030400577 hasAuthorship W2030400577A5005633411 @default.
• W2030400577 hasAuthorship W2030400577A5014947216 @default.
• W2030400577 hasAuthorship W2030400577A5015474583 @default.
• W2030400577 hasAuthorship W2030400577A5022843473 @default.
• W2030400577 hasAuthorship W2030400577A5046417463 @default.
• W2030400577 hasAuthorship W2030400577A5090097466 @default.
• W2030400577 hasAuthorship W2030400577A5091293579 @default.
• W2030400577 hasBestOaLocation W20304005771 @default.
• W2030400577 hasConcept C11988809 @default.
• W2030400577 hasConcept C120665830 @default.
• W2030400577 hasConcept C121332964 @default.
• W2030400577 hasConcept C126322002 @default.
• W2030400577 hasConcept C127413603 @default.
• W2030400577 hasConcept C159654299 @default.
• W2030400577 hasConcept C185592680 @default.
• W2030400577 hasConcept C203014093 @default.
• W2030400577 hasConcept C2776572282 @default.
• W2030400577 hasConcept C2776914184 @default.
• W2030400577 hasConcept C2778820722 @default.
• W2030400577 hasConcept C2780645631 @default.
• W2030400577 hasConcept C2781197716 @default.
• W2030400577 hasConcept C3020166492 @default.
• W2030400577 hasConcept C43044207 @default.
• W2030400577 hasConcept C541997718 @default.
• W2030400577 hasConcept C55493867 @default.
• W2030400577 hasConcept C61511704 @default.
• W2030400577 hasConcept C71924100 @default.
• W2030400577 hasConcept C78519656 @default.
• W2030400577 hasConcept C90924648 @default.
• W2030400577 hasConceptScore W2030400577C11988809 @default.
• W2030400577 hasConceptScore W2030400577C120665830 @default.
• W2030400577 hasConceptScore W2030400577C121332964 @default.
• W2030400577 hasConceptScore W2030400577C126322002 @default.
• W2030400577 hasConceptScore W2030400577C127413603 @default.
• W2030400577 hasConceptScore W2030400577C159654299 @default.
• W2030400577 hasConceptScore W2030400577C185592680 @default.
• W2030400577 hasConceptScore W2030400577C203014093 @default.
• W2030400577 hasConceptScore W2030400577C2776572282 @default.
• W2030400577 hasConceptScore W2030400577C2776914184 @default.
• W2030400577 hasConceptScore W2030400577C2778820722 @default.
• W2030400577 hasConceptScore W2030400577C2780645631 @default.

• next