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• W2030404906 abstract "Fourteen new abietane (1−14) and seven new C20-norabietane (15−21) diterpenes, together with five known analogues, have been isolated from the stem bark of Fraxinus sieboldiana. Their structures were elucidated by spectroscopic data analysis. In the in vitro assays, at 10−5 M, compounds 8, 16, and 22 showed inhibitory activity against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor, with 59.7 ± 4.8%, 56.1 ± 5.6%, and 65.9 ± 3.1% inhibition, respectively. Compound 23 was active against H5N1 avian influenza virus with an IC50 value of 4.8 μM. Compounds 3 and 5 exhibited selective cytotoxic activities against A2780 (IC50 1.7 μM) and A549 (IC50 6.0 μM), respectively." @default.
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• W2030404906 date "2010-10-20" @default.
• W2030404906 modified "2023-10-18" @default.
• W2030404906 title "Abietane and C₂₀-Norabietane Diterpenes from the Stem Bark of <i>Fraxinus sieboldiana</i> and Their Biological Activities" @default.
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• W2030404906 doi "https://doi.org/10.1021/np100583u" @default.
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