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- W2030408462 abstract "Visual cortex activity in the blind has been shown in sensory tasks. Can it be activated in memory tasks? If so, areinherent features of its organization meaningfully employed? Our recent results in short-term blindfolded subjectsimply that human primary visual cortex (V1) may operate as a modality-independent 'sketchpad' for workingmemory (Likova, 2010a). Interestingly, the spread of the V1 activation approximately corresponded to the spatialextent of the images in terms of their angle of projection to the subject. We now raise the questions of whether underlong-term visual deprivation V1 is also employed in non-visual memory task, in particular in congenitally blindindividuals, who have never had visual stimulation to guide the development of the visual area organization, andwhether such spatial organization is still valid for the same paradigm that was used in blindfolded individuals. Theoutcome has implications for an emerging reconceptualization of the principles of brain architecture and itsreorganization under sensory deprivation. Methods: We used a novel fMRI drawing paradigm in congenitally andlate-onset blind, compared with sighted and blindfolded subjects in three conditions of 20s duration, separated by20s rest-intervals, (i) Tactile Exploration: raised-line images explored and memorized; (ii) Tactile Memory Drawing:drawing the explored image from memory; (iii) Scribble: mindless drawing movements with no memory component.Results and Conclusions: V1 was strongly activated for Tactile Memory Drawing and Tactile Exploration in thesetotally blind subjects. Remarkably, after training, even in the memory task, the mapping of V1 activation largelycorresponded to the angular projection of the tactile stimuli relative to the ego-center (i.e., the effective visual angleat the head); beyond this projective boundary, peripheral V1 signals were dramatically reduced or even suppressed.The matching extent of the activation in the congenitally blind rules out vision-based explanatory mechanisms, andsupports the more radical idea of V1 as a modality-independent 'projection screen' or a 'sketchpad', whose mappingscales to the projective dimensions of objects explored in the peri-personal space." @default.
- W2030408462 created "2016-06-24" @default.
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- W2030408462 date "2012-02-05" @default.
- W2030408462 modified "2023-10-18" @default.
- W2030408462 title "The spatiotopic 'visual' cortex of the blind" @default.
- W2030408462 doi "https://doi.org/10.1117/12.912257" @default.
- W2030408462 hasPublicationYear "2012" @default.
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