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- W2030417741 abstract "Background: Patients with traumatic brain injury (TBI) are at an increased risk of developing venous thromboembolic events (VTE), including deep vein thromboses (DVT) and pulmonary emboli (PE). Pharmacologic thromboprophylaxis (PTP) is routinely delayed because of concerns of exacerbating intracranial hemorrhage (ICH) and worsening outcomes. We hypothesize that early PTP ( 72 h). Methods: We identified a total of 128 TBI patients who received PTP, and collected data including admission Glasgow coma scale (GCS), age, time of initiation of PTP, development of DVT or PE, progression of bleed on brain CT scan, death attributed to PTP and outcome (Glasgow outcome scale (GOS) at discharge from the hospital). Results: The 72 h group (n = 48). The 72 h group (odds ratio (OR) = 0.3; 95% confidence interval (CI) = 0.1 - 0.7, P = 0.01). There were no PEs, progression on brain CT, or deaths attributed to PTP in either group. Good neurologic outcome (GOS 4-5) was present in 35 (44%) patients in the 72 h group (OR = 2.6, 95% CI = 1.2 - 5.8, P = 0.01) (This outcome was expected and explained by the higher admission GCS in the 72 h). However, the safety and feasibility of early PTP in TBI still needs to be studied in large prospective multicenter trials, taking into account the severity of TBI, type of TBI (focal versus diffuse axonal injury), and type and dosage of PTP. J Neurol Res. 2013;3(6):169-172 doi: http://dx.doi.org/10.4021/jnr255w" @default.
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- W2030417741 date "2014-01-11" @default.
- W2030417741 modified "2023-10-04" @default.
- W2030417741 title "Safety and Efficacy of Early Pharmacologic Thromboprophylaxis in Traumatic Brain Injury" @default.
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- W2030417741 doi "https://doi.org/10.4021/jnr.v3i6.255" @default.
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