FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030423275> ?p ?o ?g. }

• W2030423275 endingPage "998" @default.
• W2030423275 startingPage "991" @default.
• W2030423275 abstract "Dynamic modulation of ion channels can produce dramatic alterations of electrical excitability in cardiac myocytes. This study addresses the effects of the Src family tyrosine kinase Fyn on Na(V)1.5 cardiac sodium channels. Sodium currents were acquired by whole cell recording on HEK-293 cells transiently expressing Na(V)1.5. Acute treatment of cells with insulin caused a depolarizing shift in steady-state inactivation, an effect eliminated by the Src-specific tyrosine kinase inhibitor PP2. Sodium channels were coexpressed with either constitutively active (Fyn(CA)) or catalytically inactive (Fyn(KD)) variants of Fyn. Fyn(CA) caused a 10-mV depolarizing shift of steady-state inactivation compared with Fyn(KD) without altering the activation conductance-voltage relationship. Comparable effects of these Fyn variants were obtained with whole-cell and perforated-patch recording. Tyrosine phosphorylation of immunoprecipitated Na(V)1.5 was increased in cells expressing Fyn(CA) compared with Fyn(KD). We show that Fyn is present in rat cardiac myocytes, and that Na(V)1.5 channels from these myocytes are tyrosine-phosphorylated. In HEK-293 cells the effect of Fyn(CA) on Na(V)1.5 inactivation is abolished by the single point mutation Y1495F, a residue located within the cytoplasmic linker between the third and fourth homologous domains of the sodium channel. We provide evidence that this linker is a substrate for Fyn in vitro, and that Y1495 is a preferred phosphorylation site. These results suggest that cardiac sodium channels are physiologically relevant targets of Src family tyrosine kinases." @default.
• W2030423275 created "2016-06-24" @default.
• W2030423275 creator A5038268798 @default.
• W2030423275 creator A5072552402 @default.
• W2030423275 creator A5080418456 @default.
• W2030423275 creator A5091212363 @default.
• W2030423275 date "2005-05-13" @default.
• W2030423275 modified "2023-09-25" @default.
• W2030423275 title "Modulation of the Cardiac Sodium Channel Na _V 1.5 by Fyn, a Src Family Tyrosine Kinase" @default.
• W2030423275 cites W1484215622 @default.
• W2030423275 cites W1519457709 @default.
• W2030423275 cites W1563737837 @default.
• W2030423275 cites W1964285407 @default.
• W2030423275 cites W1968903551 @default.
• W2030423275 cites W1983766023 @default.
• W2030423275 cites W1993267826 @default.
• W2030423275 cites W1995176465 @default.
• W2030423275 cites W2010048605 @default.
• W2030423275 cites W2012799858 @default.
• W2030423275 cites W2012812971 @default.
• W2030423275 cites W2017996683 @default.
• W2030423275 cites W2030854707 @default.
• W2030423275 cites W2048748125 @default.
• W2030423275 cites W2093087874 @default.
• W2030423275 cites W2096182338 @default.
• W2030423275 cites W2096306821 @default.
• W2030423275 cites W2102742081 @default.
• W2030423275 cites W2105859090 @default.
• W2030423275 cites W2108132235 @default.
• W2030423275 cites W2124474084 @default.
• W2030423275 cites W2151554161 @default.
• W2030423275 cites W2151750070 @default.
• W2030423275 cites W2155365016 @default.
• W2030423275 cites W2155985861 @default.
• W2030423275 cites W2195988565 @default.
• W2030423275 cites W4245936201 @default.
• W2030423275 doi "https://doi.org/10.1161/01.res.0000166324.00524.dd" @default.
• W2030423275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15831816" @default.
• W2030423275 hasPublicationYear "2005" @default.
• W2030423275 type Work @default.
• W2030423275 sameAs 2030423275 @default.
• W2030423275 citedByCount "92" @default.
• W2030423275 countsByYear W20304232752012 @default.
• W2030423275 countsByYear W20304232752013 @default.
• W2030423275 countsByYear W20304232752014 @default.
• W2030423275 countsByYear W20304232752015 @default.
• W2030423275 countsByYear W20304232752016 @default.
• W2030423275 countsByYear W20304232752018 @default.
• W2030423275 countsByYear W20304232752019 @default.
• W2030423275 countsByYear W20304232752020 @default.
• W2030423275 countsByYear W20304232752021 @default.
• W2030423275 countsByYear W20304232752022 @default.
• W2030423275 countsByYear W20304232752023 @default.
• W2030423275 crossrefType "journal-article" @default.
• W2030423275 hasAuthorship W2030423275A5038268798 @default.
• W2030423275 hasAuthorship W2030423275A5072552402 @default.
• W2030423275 hasAuthorship W2030423275A5080418456 @default.
• W2030423275 hasAuthorship W2030423275A5091212363 @default.
• W2030423275 hasBestOaLocation W20304232751 @default.
• W2030423275 hasConcept C108636557 @default.
• W2030423275 hasConcept C11960822 @default.
• W2030423275 hasConcept C12554922 @default.
• W2030423275 hasConcept C153911025 @default.
• W2030423275 hasConcept C178790620 @default.
• W2030423275 hasConcept C183141693 @default.
• W2030423275 hasConcept C185592680 @default.
• W2030423275 hasConcept C197153747 @default.
• W2030423275 hasConcept C2776165026 @default.
• W2030423275 hasConcept C2777553839 @default.
• W2030423275 hasConcept C2779976819 @default.
• W2030423275 hasConcept C37686147 @default.
• W2030423275 hasConcept C4141045 @default.
• W2030423275 hasConcept C42362537 @default.
• W2030423275 hasConcept C50952357 @default.
• W2030423275 hasConcept C537181965 @default.
• W2030423275 hasConcept C55493867 @default.
• W2030423275 hasConcept C62478195 @default.
• W2030423275 hasConcept C86803240 @default.
• W2030423275 hasConcept C95444343 @default.
• W2030423275 hasConceptScore W2030423275C108636557 @default.
• W2030423275 hasConceptScore W2030423275C11960822 @default.
• W2030423275 hasConceptScore W2030423275C12554922 @default.
• W2030423275 hasConceptScore W2030423275C153911025 @default.
• W2030423275 hasConceptScore W2030423275C178790620 @default.
• W2030423275 hasConceptScore W2030423275C183141693 @default.
• W2030423275 hasConceptScore W2030423275C185592680 @default.
• W2030423275 hasConceptScore W2030423275C197153747 @default.
• W2030423275 hasConceptScore W2030423275C2776165026 @default.
• W2030423275 hasConceptScore W2030423275C2777553839 @default.
• W2030423275 hasConceptScore W2030423275C2779976819 @default.
• W2030423275 hasConceptScore W2030423275C37686147 @default.
• W2030423275 hasConceptScore W2030423275C4141045 @default.
• W2030423275 hasConceptScore W2030423275C42362537 @default.
• W2030423275 hasConceptScore W2030423275C50952357 @default.
• W2030423275 hasConceptScore W2030423275C537181965 @default.
• W2030423275 hasConceptScore W2030423275C55493867 @default.
• W2030423275 hasConceptScore W2030423275C62478195 @default.
• W2030423275 hasConceptScore W2030423275C86803240 @default.

• next