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• W2030426525 abstract "The hippocampus of adult mammals including humans continues to generate neurons throughout life. The neural stem/progenitor cells, the cellular phenotype responsible for this regenerative capacity, are a subject of intensive research focused on the mechanisms of their regulation. Intriguing recent data implicate an unexpected molecular player in this regulation: free fatty acids. Polyunsaturated fatty acids (PUFA) such as docosahexaenoic and arachidonic acids were identified to act on the pancreas via a novel receptor, named G-protein coupled receptor 40 (GPR40). However, the pancreas appears not to be the single target organ of PUFA/GPR40 actions. Very recent findings have discovered GPR40 expression in the hippocampal dentate gyrus, including its progenitor cell niche responsible for neuronal renewal throughout life. These data open a possibility that PUFA may regulate adult hippocampal neurogenesis and thus become a therapeutic tool to treat neurological disorders in humans. Biomedical Reviews 2007; 18: 69-73." @default.
• W2030426525 created "2016-06-24" @default.
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• W2030426525 date "2007-12-31" @default.
• W2030426525 modified "2023-09-23" @default.
• W2030426525 title "Fatty acids as regulators of hippocampal neurogenesis: the case of GPR40" @default.
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• W2030426525 doi "https://doi.org/10.14748/bmr.v18.70" @default.
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