Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030429038> ?p ?o ?g. }
- W2030429038 endingPage "2158" @default.
- W2030429038 startingPage "2147" @default.
- W2030429038 abstract "The main limitation of gene therapy towards clinics is the lack of robust, safe and efficient gene delivery vectors. This paper describes new polycations for gene delivery based on poly(β-amino ester)s (pBAE) containing terminal oligopeptides. The authors developed oligopeptide-modified pBAE-pDNA nanoparticles that achieve better cellular viability and higher transfection efficacy than other end-modified pBAE and commercial transfection agents. Gene expression in highly permissive cell lines was remarkably high, but transfection efficiency in less-permissive cell lines was highly dependent on oligopeptide composition and nanoparticle formulation. Moreover, the use of selected oligopeptides in the pBAE formulation led to preferential intracellular localization of the particles. Particle analysis of highly efficient pBAE formulations revealed different particle sizes and charge features, which indicates chemical pseudotyping of the particle surface, related to the oligopeptide chemical nature. In conclusion, chemical modification at the termini of pBAE with amine-rich oligopeptides is a powerful strategy for developing delivery systems for future gene therapy applications." @default.
- W2030429038 created "2016-06-24" @default.
- W2030429038 creator A5004660816 @default.
- W2030429038 creator A5014461749 @default.
- W2030429038 creator A5030197584 @default.
- W2030429038 creator A5047553777 @default.
- W2030429038 creator A5054051212 @default.
- W2030429038 date "2014-05-01" @default.
- W2030429038 modified "2023-09-27" @default.
- W2030429038 title "Oligopeptide-terminated poly(β-amino ester)s for highly efficient gene delivery and intracellular localization" @default.
- W2030429038 cites W1556094015 @default.
- W2030429038 cites W1579604458 @default.
- W2030429038 cites W1587913196 @default.
- W2030429038 cites W16501288 @default.
- W2030429038 cites W1963875915 @default.
- W2030429038 cites W1968113316 @default.
- W2030429038 cites W1972128873 @default.
- W2030429038 cites W1975513471 @default.
- W2030429038 cites W1977255778 @default.
- W2030429038 cites W1983275470 @default.
- W2030429038 cites W1983865998 @default.
- W2030429038 cites W1984739176 @default.
- W2030429038 cites W1985222229 @default.
- W2030429038 cites W1987723433 @default.
- W2030429038 cites W1990434569 @default.
- W2030429038 cites W1993844364 @default.
- W2030429038 cites W1997446043 @default.
- W2030429038 cites W1999228064 @default.
- W2030429038 cites W2000136129 @default.
- W2030429038 cites W2004180909 @default.
- W2030429038 cites W2008028087 @default.
- W2030429038 cites W2011085652 @default.
- W2030429038 cites W2018616490 @default.
- W2030429038 cites W2023543867 @default.
- W2030429038 cites W2029380542 @default.
- W2030429038 cites W2038354932 @default.
- W2030429038 cites W2045052963 @default.
- W2030429038 cites W2046312023 @default.
- W2030429038 cites W2046406980 @default.
- W2030429038 cites W2050891199 @default.
- W2030429038 cites W2052478070 @default.
- W2030429038 cites W2055573906 @default.
- W2030429038 cites W2056224696 @default.
- W2030429038 cites W2061445615 @default.
- W2030429038 cites W2068586723 @default.
- W2030429038 cites W2068834611 @default.
- W2030429038 cites W2069693261 @default.
- W2030429038 cites W2071404720 @default.
- W2030429038 cites W2077364459 @default.
- W2030429038 cites W2081644109 @default.
- W2030429038 cites W2083339685 @default.
- W2030429038 cites W2084976117 @default.
- W2030429038 cites W2086069830 @default.
- W2030429038 cites W2086138918 @default.
- W2030429038 cites W2086245096 @default.
- W2030429038 cites W2088564088 @default.
- W2030429038 cites W2093685827 @default.
- W2030429038 cites W2094399039 @default.
- W2030429038 cites W2099067417 @default.
- W2030429038 cites W2107161595 @default.
- W2030429038 cites W2111424797 @default.
- W2030429038 cites W2111994795 @default.
- W2030429038 cites W2113972541 @default.
- W2030429038 cites W2121413068 @default.
- W2030429038 cites W2121811064 @default.
- W2030429038 cites W2124198483 @default.
- W2030429038 cites W2127685088 @default.
- W2030429038 cites W2133437356 @default.
- W2030429038 cites W2138324018 @default.
- W2030429038 cites W2139251684 @default.
- W2030429038 cites W2144696689 @default.
- W2030429038 cites W2149896139 @default.
- W2030429038 cites W2157479160 @default.
- W2030429038 cites W2158254083 @default.
- W2030429038 cites W2162029104 @default.
- W2030429038 cites W2162962263 @default.
- W2030429038 cites W2170390976 @default.
- W2030429038 cites W288331025 @default.
- W2030429038 cites W2949091778 @default.
- W2030429038 doi "https://doi.org/10.1016/j.actbio.2013.12.054" @default.
- W2030429038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24406199" @default.
- W2030429038 hasPublicationYear "2014" @default.
- W2030429038 type Work @default.
- W2030429038 sameAs 2030429038 @default.
- W2030429038 citedByCount "62" @default.
- W2030429038 countsByYear W20304290382014 @default.
- W2030429038 countsByYear W20304290382015 @default.
- W2030429038 countsByYear W20304290382016 @default.
- W2030429038 countsByYear W20304290382017 @default.
- W2030429038 countsByYear W20304290382018 @default.
- W2030429038 countsByYear W20304290382019 @default.
- W2030429038 countsByYear W20304290382020 @default.
- W2030429038 countsByYear W20304290382021 @default.
- W2030429038 countsByYear W20304290382022 @default.
- W2030429038 countsByYear W20304290382023 @default.
- W2030429038 crossrefType "journal-article" @default.
- W2030429038 hasAuthorship W2030429038A5004660816 @default.
- W2030429038 hasAuthorship W2030429038A5014461749 @default.