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- W2030429879 abstract "To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release.A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were compared; the in situ forming microparticle (ISM) and the emulsion-solvent evaporation (ESE) methods using an experimental design. The MPs obtained were compared according to their physical characterization, burst release and T80%. An in vivo pharmacokinetic study with in vitro-in vivo correlation (IVIVC) was also performed for the selected formula.Both methods were able to sustain drug release for three weeks. ISM produced more porous particles and was not effective as ESE for controlling burst release. A good IVIVC (R(2) = 0.9755) was attained when injecting the selected formula into rats.MPs prepared with ESE showed a minimum burst release and a level A IVIVC was obtained when administered to rats." @default.
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- W2030429879 date "2014-06-25" @default.
- W2030429879 modified "2023-10-18" @default.
- W2030429879 title "Impact of microparticle formulation approaches on drug burst release: a level A IVIVC" @default.
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- W2030429879 doi "https://doi.org/10.3109/02652048.2014.913724" @default.
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