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- W2030432005 abstract "We have generated connexin30.3-deficient mice in which the coding region of the connexin30.3 gene was replaced by the lacZ reporter gene. The expression pattern of this connexin was characterized using β-galactosidase staining and immunoblot analyses. In skin, β-galactosidase/connexin30.3 protein was expressed in the spinous and granulous layers of the epidermis. Specific β-galactosidase/connexin30.3 expression was also detected in the thin ascending limb of Henle's loop in the kidney. In addition, we found β-galactosidase/connexin30.3 in progenitor cells of the olfactory epithelium and in a subpopulation of cells in the apical layer of the vomeronasal organ. Connexin30.3-deficient mice were fertile and displayed no abnormalities in the skin or in the chemosensory systems. Furthermore, they showed normal auditory thresholds as measured by brain stem evoked potentials. These mice did, however, exhibit reduced behavioural responses to a vanilla scent." @default.
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- W2030432005 date "2007-12-01" @default.
- W2030432005 modified "2023-10-16" @default.
- W2030432005 title "Characterization of connexin30.3-deficient mice suggests a possible role of connexin30.3 in olfaction" @default.
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- W2030432005 doi "https://doi.org/10.1016/j.ejcb.2007.01.005" @default.
- W2030432005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17728008" @default.
- W2030432005 hasPublicationYear "2007" @default.
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