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• W2030434462 abstract "The C-509T polymorphism of TGF-beta(1) gene has been associated with asthma and atopy in white populations.We investigated the association between asthma and previously identified polymorphisms at C-509T and T869C of the TGF-beta(1) gene among 250 Chinese patients with asthma and 308 healthy controls in Hong Kong.Genotyping was performed on peripheral blood genomic DNA by using PCR-RFLP.There were no differences in the frequencies of genotypes and alleles between patients and controls. The C-509T and T869C polymorphisms were in tight linkage disequilibrium (P < .01). Among atopic subjects, significant differences were found in genotype and allele frequencies for T869C polymorphism between patients and controls (P = .014 and P = .019, respectively), and individuals bearing the CC genotype were associated with increased risk for the development of asthma (odds ratio, 2.58; 95% CI, 1.17-5.66; P = .018) after adjusting for age, sex, and smoking status. Individuals with asthma bearing the CT genotype of the C-509T polymorphism had significantly increased risk for severe airflow obstruction compared with individuals who had mild obstruction (odds ratio, 4.00; 95% CI, 1.06-15.08; P = .035).Our results indicate that the polymorphisms at C-509T and T869C of the TGF-beta(1) gene are associated with asthma susceptibility in atopic subjects of the Hong Kong Chinese population, and the C-509T polymorphism may play a role in the pathogenesis of airflow obstruction." @default.
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• W2030434462 date "2006-01-01" @default.
• W2030434462 modified "2023-10-08" @default.
• W2030434462 title "Analysis of TGF-β1 gene polymorphisms in Hong Kong Chinese patients with asthma" @default.
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• W2030434462 doi "https://doi.org/10.1016/j.jaci.2005.08.049" @default.
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