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- W2030436706 abstract "Significance When cells sense changes in their environment, molecular pathways relay information to the transcriptional machinery, which induces gene expression changes that allow for adaptation to the new conditions. In this paper, the C-terminal domain (CTD) of the RNA polymerase II largest subunit is shown to be involved in adaptation of yeast cells to conditions of low phosphate levels and where galactose is the primary fuel source. Specifically, threonine residues within the repeated CTD structure are required for induction of genes involved in phosphate and galactose metabolism, by stimulating the eviction of the histone variant Htz1 from the gene promoters. This finding reveals a role for the CTD in chromatin remodeling that facilitates expression of specific genes." @default.
- W2030436706 created "2016-06-24" @default.
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- W2030436706 date "2014-07-28" @default.
- W2030436706 modified "2023-10-04" @default.
- W2030436706 title "Threonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling" @default.
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- W2030436706 doi "https://doi.org/10.1073/pnas.1412802111" @default.
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