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- W2030441199 abstract "Administration of endogenous corticosterone to intact animals induces calbindin-D28kprotein in the hippocampal CA1–CA2 subfields. The fact that this effect on calbindin-D28kwas shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with corticosterone aggravates ischemia-induced neuronal damage in the CA3–CA4 subfields. This effect is similar to that of preischemic hyperglycemia, which also induces postischemic seizures and aggravates brain damage, since corticosterone raises blood glucose level and enhances tissue lactic acidosis during ischemia. The energetically compromising qualities of corticosterone indicates that it is a key factor in hippocampal vulnerability. We assume that the increase of calbindin-D28kexpression in the CA1–CA2 subfields in corticosterone-treated animals is an adaptive response to the exogenous stress. The lack of adaptive response in CA3–CA4 neurons endangers them by impairing the ability of these neurons to counteract the deleterious effects of calcium. This finding, supports: (1) the hypothesis that corticosterone treatment, when paired with an ischemic insult, causes a prolonged elevation of neuronal [Ca2+]i, in an energy dependent manner, probably through the reduction of calcium efflux and (2) that neurons which do contain calbindin-D28kare particularly predisposed to ischemic insults. The CA1–CA2 neurons express high amounts of calbindin-D28kunder stress conditions because their activity may involve a high rate of calcium buffering." @default.
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- W2030441199 date "1998-02-01" @default.
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- W2030441199 title "Synergy between Chronic Corticosterone Treatment and Cerebral Ischemia in Producing Damage in Noncalbindinergic Neurons" @default.
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- W2030441199 doi "https://doi.org/10.1006/exnr.1997.6729" @default.
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