FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030442521> ?p ?o ?g. }

• W2030442521 endingPage "1102" @default.
• W2030442521 startingPage "1102" @default.
• W2030442521 abstract "This study was designed to assess intraobserver and interobserver agreement in the diagnosis of 56 endometrial specimens by five European expert gynecologic pathologists using the WHO classification and to establish which histologic features are significantly associated with each classification category. The seven categories were simple hyperplasia, complex hyperplasia, atypical hyperplasia, well-differentiated adenocarcinoma, proliferative endometria, secretory endometria, and other. Slides were reviewed twice for diagnosis, with accompanying evaluation of a checklist of histologic features. These seven categories were eventually reduced to four and three for the purposes of data analysis. The four modified diagnostic categories consisted of hyperplasia (previously simple hyperplasia and complex hyperplasia), atypical hyperplasia, well-differentiated adenocarcinoma, and cyclical endometrium (previously proliferative, secretory, and other). The three diagnostic categories consisted of hyperplasia, endometrioid neoplasia (previously atypical hyperplasia and well-differentiated adenocarcinoma), and cyclical endometrium. Intraobserver and interobserver agreement was assessed using the percentage agreement and kappa statistics. The associations among the various histologic features and diagnoses was analyzed using multiple logistic regression to identify those features that were useful for distinguishing diagnostic categories. When using seven categories, kappa values ranged from 0.53 to 0.74 (percentage agreement, 61-79%) and from 0.33 to 0.59 (percentage agreement, 43-63%) for intraobserver and interobserver agreement, respectively. When using four categories, kappa values ranged from 0.68 to 0.73 (percentage agreement, 77-80%) and from 0.39 to 0.64 (percentage agreement, 54-73%) for intraobserver and interobserver agreement, respectively. When using three categories, kappa values ranged from 0.70 to 0.83 (percentage agreement, 80-89%) and from 0.55 to 0.73 (percentage agreement, 70-82%) for intraobserver and interobserver agreement, respectively. Data were analyzed in each diagnostic category. When using four or three diagnostic categories, the mean intraobserver and interobserver agreements varied less between categories and achieved higher values, with smaller 95% confidence intervals. The mean percentage agreement was lowest for complex hyperplasia and for atypical hyperplasia. For distinguishing cyclical endometrium versus hyperplasia, the useful histologic feature was glandular crowding. For hyperplasia versus atypical hyperplasia and for hyperplasia versus endometrioid neoplasia, the useful features were nuclear enlargement, nuclear pleomorphism, vesicular chromatin, and nucleoli, but of these, only nuclear pleomorphism achieved substantial mean intraobserver and interobserver agreements. For discriminating atypical hyperplasia from well-differentiated adenocarcinoma, the only useful feature was stromal alterations, which achieved only fair mean intraobserver and interobserver agreements. In summary, in endometrial biopsy or curettage specimens, the lack of agreement in the diagnoses of complex hyperplasia and atypical hyperplasia and the lack of reproducibility in the recognition of the histologic feature of stromal alterations to differentiate atypical hyperplasia from well-differentiated adenocarcinoma suggest that the histologic classification should be simplified by including a combined category for simple and complex hyperplasia, called hyperplasia, and a combined category for atypical hyperplasia and well-differentiated adenocarcinoma, called endometrioid neoplasia. Diagnoses of hyperplasia and endometrioid neoplasia are highly reproducible between observers from different institutions. Glandular crowding is the best histologic feature to differentiate cyclical endometrium from hyperplasia, whereas nuclear pleomorphism is the reproducible cytologic feature to differentiate hyperplasia from endometrioid neoplasia." @default.
• W2030442521 created "2016-06-24" @default.
• W2030442521 creator A5006608114 @default.
• W2030442521 creator A5021671909 @default.
• W2030442521 creator A5027258881 @default.
• W2030442521 creator A5048740187 @default.
• W2030442521 creator A5072538504 @default.
• W2030442521 creator A5075184480 @default.
• W2030442521 creator A5085346183 @default.
• W2030442521 creator A5087019846 @default.
• W2030442521 date "1999-09-01" @default.
• W2030442521 modified "2023-10-08" @default.
• W2030442521 title "A Multicentric European Study Testing the Reproducibility of the WHO Classification of Endometrial Hyperplasia With a Proposal of a Simplified Working Classification for Biopsy and Curettage Specimens" @default.
• W2030442521 cites W1580892837 @default.
• W2030442521 cites W1627871665 @default.
• W2030442521 cites W1643388074 @default.
• W2030442521 cites W1973733252 @default.
• W2030442521 cites W1978135679 @default.
• W2030442521 cites W1991534174 @default.
• W2030442521 cites W1997098766 @default.
• W2030442521 cites W2004259949 @default.
• W2030442521 cites W2028892679 @default.
• W2030442521 cites W2036293145 @default.
• W2030442521 cites W2046352003 @default.
• W2030442521 cites W2051078146 @default.
• W2030442521 cites W2064617101 @default.
• W2030442521 cites W2070268256 @default.
• W2030442521 cites W2097113048 @default.
• W2030442521 cites W2114492159 @default.
• W2030442521 cites W2164777277 @default.
• W2030442521 cites W2167813864 @default.
• W2030442521 cites W2392679799 @default.
• W2030442521 doi "https://doi.org/10.1097/00000478-199909000-00014" @default.
• W2030442521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10478671" @default.
• W2030442521 hasPublicationYear "1999" @default.
• W2030442521 type Work @default.
• W2030442521 sameAs 2030442521 @default.
• W2030442521 citedByCount "214" @default.
• W2030442521 countsByYear W20304425212012 @default.
• W2030442521 countsByYear W20304425212013 @default.
• W2030442521 countsByYear W20304425212014 @default.
• W2030442521 countsByYear W20304425212015 @default.
• W2030442521 countsByYear W20304425212016 @default.
• W2030442521 countsByYear W20304425212017 @default.
• W2030442521 countsByYear W20304425212018 @default.
• W2030442521 countsByYear W20304425212019 @default.
• W2030442521 countsByYear W20304425212020 @default.
• W2030442521 countsByYear W20304425212021 @default.
• W2030442521 countsByYear W20304425212022 @default.
• W2030442521 countsByYear W20304425212023 @default.
• W2030442521 crossrefType "journal-article" @default.
• W2030442521 hasAuthorship W2030442521A5006608114 @default.
• W2030442521 hasAuthorship W2030442521A5021671909 @default.
• W2030442521 hasAuthorship W2030442521A5027258881 @default.
• W2030442521 hasAuthorship W2030442521A5048740187 @default.
• W2030442521 hasAuthorship W2030442521A5072538504 @default.
• W2030442521 hasAuthorship W2030442521A5075184480 @default.
• W2030442521 hasAuthorship W2030442521A5085346183 @default.
• W2030442521 hasAuthorship W2030442521A5087019846 @default.
• W2030442521 hasConcept C119857082 @default.
• W2030442521 hasConcept C121608353 @default.
• W2030442521 hasConcept C126322002 @default.
• W2030442521 hasConcept C126838900 @default.
• W2030442521 hasConcept C138885662 @default.
• W2030442521 hasConcept C142724271 @default.
• W2030442521 hasConcept C163864269 @default.
• W2030442521 hasConcept C2775904963 @default.
• W2030442521 hasConcept C2775934546 @default.
• W2030442521 hasConcept C2777562237 @default.
• W2030442521 hasConcept C2777689261 @default.
• W2030442521 hasConcept C2778724333 @default.
• W2030442521 hasConcept C2779904257 @default.
• W2030442521 hasConcept C2781182431 @default.
• W2030442521 hasConcept C41008148 @default.
• W2030442521 hasConcept C41895202 @default.
• W2030442521 hasConcept C71924100 @default.
• W2030442521 hasConceptScore W2030442521C119857082 @default.
• W2030442521 hasConceptScore W2030442521C121608353 @default.
• W2030442521 hasConceptScore W2030442521C126322002 @default.
• W2030442521 hasConceptScore W2030442521C126838900 @default.
• W2030442521 hasConceptScore W2030442521C138885662 @default.
• W2030442521 hasConceptScore W2030442521C142724271 @default.
• W2030442521 hasConceptScore W2030442521C163864269 @default.
• W2030442521 hasConceptScore W2030442521C2775904963 @default.
• W2030442521 hasConceptScore W2030442521C2775934546 @default.
• W2030442521 hasConceptScore W2030442521C2777562237 @default.
• W2030442521 hasConceptScore W2030442521C2777689261 @default.
• W2030442521 hasConceptScore W2030442521C2778724333 @default.
• W2030442521 hasConceptScore W2030442521C2779904257 @default.
• W2030442521 hasConceptScore W2030442521C2781182431 @default.
• W2030442521 hasConceptScore W2030442521C41008148 @default.
• W2030442521 hasConceptScore W2030442521C41895202 @default.
• W2030442521 hasConceptScore W2030442521C71924100 @default.
• W2030442521 hasIssue "9" @default.
• W2030442521 hasLocation W20304425211 @default.
• W2030442521 hasLocation W20304425212 @default.
• W2030442521 hasOpenAccess W2030442521 @default.
• W2030442521 hasPrimaryLocation W20304425211 @default.

• next