FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030443316> ?p ?o ?g. }

• W2030443316 endingPage "1739" @default.
• W2030443316 startingPage "1732" @default.
• W2030443316 abstract "Indole-3-carbinol (I3C) is a compound found in high concentrations in Brassica family vegetables, including broccoli, cauliflower and cabbage, and is regarded as a promising chemopreventive agent against various cancers. This study assesses the protective effect of I3C against diet-induced obesity in mice. Mice were randomly grouped to receive either a normal diet, high-fat (40% energy as fat) diet (HFD) or I3C-supplemented diet (1 g/kg diet) for 10 weeks. I3C supplementation significantly ameliorated HFD-induced increases in body weight gain, visceral fat pad weights and plasma lipid levels. The visceral adipose tissue mRNA levels of uncoupling proteins 1 and 3, crucial factors of thermogenesis, and their regulators such as sirtuin 1, peroxisome proliferator-activated receptor (PPAR) α and PPARγ coactivator 1α, which were down-regulated by HFD, were normalized by supplementation with I3C. In contrast, I3C supplementation significantly decreased expression levels of a key adipogenic transcription factor, PPARγ2, and its target genes, such as leptin and adipocyte protein 2, in the visceral adipose tissue of mice maintained on the HFD. Furthermore, HFD-induced up-regulation in mRNA levels of inflammatory cytokines (tumor necrosis factor α, interferon β and interleukin 6) was significantly ameliorated by I3C. These findings suggest that I3C has a potential benefit in preventing obesity and metabolic disorders, and the action for I3C in vivo may involve multiple mechanisms including decreased adipogenesis and inflammation, along with activated thermogenesis." @default.
• W2030443316 created "2016-06-24" @default.
• W2030443316 creator A5005282042 @default.
• W2030443316 creator A5006050449 @default.
• W2030443316 creator A5018749748 @default.
• W2030443316 creator A5025326383 @default.
• W2030443316 creator A5062982950 @default.
• W2030443316 date "2012-12-01" @default.
• W2030443316 modified "2023-09-27" @default.
• W2030443316 title "Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice" @default.
• W2030443316 cites W1489925379 @default.
• W2030443316 cites W1575263278 @default.
• W2030443316 cites W1930598094 @default.
• W2030443316 cites W1998705913 @default.
• W2030443316 cites W1999159221 @default.
• W2030443316 cites W2002519246 @default.
• W2030443316 cites W2004130992 @default.
• W2030443316 cites W2007751980 @default.
• W2030443316 cites W2021650594 @default.
• W2030443316 cites W2024890638 @default.
• W2030443316 cites W2028370541 @default.
• W2030443316 cites W2046094959 @default.
• W2030443316 cites W2079389643 @default.
• W2030443316 cites W2081743448 @default.
• W2030443316 cites W2088203053 @default.
• W2030443316 cites W2092705103 @default.
• W2030443316 cites W2115185894 @default.
• W2030443316 cites W2119193879 @default.
• W2030443316 cites W2130533170 @default.
• W2030443316 cites W2136601392 @default.
• W2030443316 cites W2140936516 @default.
• W2030443316 cites W2143642040 @default.
• W2030443316 cites W2152101492 @default.
• W2030443316 cites W2157510347 @default.
• W2030443316 cites W2165745035 @default.
• W2030443316 cites W2171835251 @default.
• W2030443316 cites W2175474731 @default.
• W2030443316 doi "https://doi.org/10.1016/j.jnutbio.2011.12.005" @default.
• W2030443316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22569347" @default.
• W2030443316 hasPublicationYear "2012" @default.
• W2030443316 type Work @default.
• W2030443316 sameAs 2030443316 @default.
• W2030443316 citedByCount "60" @default.
• W2030443316 countsByYear W20304433162012 @default.
• W2030443316 countsByYear W20304433162013 @default.
• W2030443316 countsByYear W20304433162014 @default.
• W2030443316 countsByYear W20304433162015 @default.
• W2030443316 countsByYear W20304433162016 @default.
• W2030443316 countsByYear W20304433162017 @default.
• W2030443316 countsByYear W20304433162018 @default.
• W2030443316 countsByYear W20304433162019 @default.
• W2030443316 countsByYear W20304433162020 @default.
• W2030443316 countsByYear W20304433162021 @default.
• W2030443316 countsByYear W20304433162022 @default.
• W2030443316 countsByYear W20304433162023 @default.
• W2030443316 crossrefType "journal-article" @default.
• W2030443316 hasAuthorship W2030443316A5005282042 @default.
• W2030443316 hasAuthorship W2030443316A5006050449 @default.
• W2030443316 hasAuthorship W2030443316A5018749748 @default.
• W2030443316 hasAuthorship W2030443316A5025326383 @default.
• W2030443316 hasAuthorship W2030443316A5062982950 @default.
• W2030443316 hasConcept C104317684 @default.
• W2030443316 hasConcept C122927707 @default.
• W2030443316 hasConcept C126322002 @default.
• W2030443316 hasConcept C127561419 @default.
• W2030443316 hasConcept C134018914 @default.
• W2030443316 hasConcept C151279926 @default.
• W2030443316 hasConcept C170493617 @default.
• W2030443316 hasConcept C171089720 @default.
• W2030443316 hasConcept C187345961 @default.
• W2030443316 hasConcept C194832188 @default.
• W2030443316 hasConcept C2776175234 @default.
• W2030443316 hasConcept C2776536020 @default.
• W2030443316 hasConcept C2776914184 @default.
• W2030443316 hasConcept C2780613262 @default.
• W2030443316 hasConcept C511355011 @default.
• W2030443316 hasConcept C55493867 @default.
• W2030443316 hasConcept C71924100 @default.
• W2030443316 hasConcept C81979416 @default.
• W2030443316 hasConcept C86803240 @default.
• W2030443316 hasConceptScore W2030443316C104317684 @default.
• W2030443316 hasConceptScore W2030443316C122927707 @default.
• W2030443316 hasConceptScore W2030443316C126322002 @default.
• W2030443316 hasConceptScore W2030443316C127561419 @default.
• W2030443316 hasConceptScore W2030443316C134018914 @default.
• W2030443316 hasConceptScore W2030443316C151279926 @default.
• W2030443316 hasConceptScore W2030443316C170493617 @default.
• W2030443316 hasConceptScore W2030443316C171089720 @default.
• W2030443316 hasConceptScore W2030443316C187345961 @default.
• W2030443316 hasConceptScore W2030443316C194832188 @default.
• W2030443316 hasConceptScore W2030443316C2776175234 @default.
• W2030443316 hasConceptScore W2030443316C2776536020 @default.
• W2030443316 hasConceptScore W2030443316C2776914184 @default.
• W2030443316 hasConceptScore W2030443316C2780613262 @default.
• W2030443316 hasConceptScore W2030443316C511355011 @default.
• W2030443316 hasConceptScore W2030443316C55493867 @default.
• W2030443316 hasConceptScore W2030443316C71924100 @default.
• W2030443316 hasConceptScore W2030443316C81979416 @default.

• next