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• W2030446871 startingPage "1661" @default.
• W2030446871 abstract "The introduction of vaccines containing the capsular polysaccharides of N. meningitidis, S. pneumonia, and H. influenzae type b has driven a significant reduction in cases of disease caused by these bacteria. The polysaccharide-specific antibody responses following vaccination are well characterized, however less is known about the B cells underlying this response. Here, we summarize the plasma cell (PC) and memory B cell (BMEM) responses following plain polysaccharide and protein-polysaccharide conjugate vaccination, drawing together studies covering a range of vaccines and age groups. These studies show that infant primary PC and BMEM responses to polysaccharide-conjugate vaccines are low in relation to older age groups but are significantly higher following booster doses. PC kinetics have generally been found to follow a similar pattern irrespective of vaccine type or age group, whereas divergent BMEM responses have been reported following plain polysaccharide and conjugate vaccination. A degree of correlation between early BMEM responses and maintenance of protective antibody levels has been identified in some studies, but the relationship between the 2 remains unclear. Identification of the B cell subsets involved and the mechanisms by which they are induced may provide a better understanding of the role of B cells in maintaining protective immunity through vaccination." @default.
• W2030446871 created "2016-06-24" @default.
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• W2030446871 date "2014-03-14" @default.
• W2030446871 modified "2023-09-29" @default.
• W2030446871 title "Polysaccharide-specific B cell responses to vaccination in humans" @default.
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• W2030446871 doi "https://doi.org/10.4161/hv.28350" @default.
• W2030446871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5396230" @default.
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• W2030446871 hasPublicationYear "2014" @default.
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