FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030460047> ?p ?o ?g. }

• W2030460047 abstract "Abstract Background Cleavage of messenger RNA (mRNA) precursors is an essential step in mRNA maturation. The signal recognized by the cleavage enzyme complex has been characterized as an A rich region upstream of the cleavage site containing a motif with consensus AAUAAA, followed by a U or UG rich region downstream of the cleavage site. Results We studied these signals using exhaustive databases of cleavage sites obtained from aligning raw expressed sequence tags (EST) sequences to genomic sequences in Homo sapiens and Drosophila melanogaster . These data show that the polyadenylation signal is highly conserved in human and fly. In addition, de novo motif searches generated a refined description of the U-rich downstream sequence (DSE) element, which shows more divergence between the two species. These refined motifs are applied, within a Hidden Markov Model (HMM) framework, to predict mRNA cleavage sites. Conclusion We demonstrate that the DSE is a specific motif in both human and Drosophila . These findings shed light on the sequence correlates of a highly conserved biological process, and improve in silico prediction of 3' mRNA cleavage and polyadenylation sites." @default.
• W2030460047 created "2016-06-24" @default.
• W2030460047 creator A5017898962 @default.
• W2030460047 creator A5045537456 @default.
• W2030460047 creator A5071339188 @default.
• W2030460047 creator A5074106693 @default.
• W2030460047 creator A5089520399 @default.
• W2030460047 date "2006-07-12" @default.
• W2030460047 modified "2023-10-09" @default.
• W2030460047 title "Similarities and differences of polyadenylation signals in human and fly" @default.
• W2030460047 cites W1592870802 @default.
• W2030460047 cites W1606770439 @default.
• W2030460047 cites W1749659233 @default.
• W2030460047 cites W1770412798 @default.
• W2030460047 cites W1976007281 @default.
• W2030460047 cites W1989967763 @default.
• W2030460047 cites W1995824852 @default.
• W2030460047 cites W1996831533 @default.
• W2030460047 cites W2020490094 @default.
• W2030460047 cites W2044648543 @default.
• W2030460047 cites W2058034836 @default.
• W2030460047 cites W2058262378 @default.
• W2030460047 cites W2076184693 @default.
• W2030460047 cites W2105545925 @default.
• W2030460047 cites W2110946097 @default.
• W2030460047 cites W2119651978 @default.
• W2030460047 cites W2129429612 @default.
• W2030460047 cites W2131446214 @default.
• W2030460047 cites W2134057866 @default.
• W2030460047 cites W2140006817 @default.
• W2030460047 cites W2151562469 @default.
• W2030460047 cites W2158634288 @default.
• W2030460047 cites W2159541136 @default.
• W2030460047 cites W2159554382 @default.
• W2030460047 cites W2166187656 @default.
• W2030460047 doi "https://doi.org/10.1186/1471-2164-7-176" @default.
• W2030460047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1574307" @default.
• W2030460047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16836751" @default.
• W2030460047 hasPublicationYear "2006" @default.
• W2030460047 type Work @default.
• W2030460047 sameAs 2030460047 @default.
• W2030460047 citedByCount "49" @default.
• W2030460047 countsByYear W20304600472012 @default.
• W2030460047 countsByYear W20304600472013 @default.
• W2030460047 countsByYear W20304600472014 @default.
• W2030460047 countsByYear W20304600472015 @default.
• W2030460047 countsByYear W20304600472016 @default.
• W2030460047 countsByYear W20304600472017 @default.
• W2030460047 countsByYear W20304600472018 @default.
• W2030460047 countsByYear W20304600472019 @default.
• W2030460047 countsByYear W20304600472020 @default.
• W2030460047 countsByYear W20304600472022 @default.
• W2030460047 countsByYear W20304600472023 @default.
• W2030460047 crossrefType "journal-article" @default.
• W2030460047 hasAuthorship W2030460047A5017898962 @default.
• W2030460047 hasAuthorship W2030460047A5045537456 @default.
• W2030460047 hasAuthorship W2030460047A5071339188 @default.
• W2030460047 hasAuthorship W2030460047A5074106693 @default.
• W2030460047 hasAuthorship W2030460047A5089520399 @default.
• W2030460047 hasBestOaLocation W20304600471 @default.
• W2030460047 hasConcept C104317684 @default.
• W2030460047 hasConcept C105580179 @default.
• W2030460047 hasConcept C117745874 @default.
• W2030460047 hasConcept C133672593 @default.
• W2030460047 hasConcept C142575336 @default.
• W2030460047 hasConcept C151730666 @default.
• W2030460047 hasConcept C167625842 @default.
• W2030460047 hasConcept C175156509 @default.
• W2030460047 hasConcept C199216141 @default.
• W2030460047 hasConcept C2775905019 @default.
• W2030460047 hasConcept C2780104201 @default.
• W2030460047 hasConcept C43369102 @default.
• W2030460047 hasConcept C54355233 @default.
• W2030460047 hasConcept C62531158 @default.
• W2030460047 hasConcept C67492840 @default.
• W2030460047 hasConcept C67705224 @default.
• W2030460047 hasConcept C70721500 @default.
• W2030460047 hasConcept C86803240 @default.
• W2030460047 hasConceptScore W2030460047C104317684 @default.
• W2030460047 hasConceptScore W2030460047C105580179 @default.
• W2030460047 hasConceptScore W2030460047C117745874 @default.
• W2030460047 hasConceptScore W2030460047C133672593 @default.
• W2030460047 hasConceptScore W2030460047C142575336 @default.
• W2030460047 hasConceptScore W2030460047C151730666 @default.
• W2030460047 hasConceptScore W2030460047C167625842 @default.
• W2030460047 hasConceptScore W2030460047C175156509 @default.
• W2030460047 hasConceptScore W2030460047C199216141 @default.
• W2030460047 hasConceptScore W2030460047C2775905019 @default.
• W2030460047 hasConceptScore W2030460047C2780104201 @default.
• W2030460047 hasConceptScore W2030460047C43369102 @default.
• W2030460047 hasConceptScore W2030460047C54355233 @default.
• W2030460047 hasConceptScore W2030460047C62531158 @default.
• W2030460047 hasConceptScore W2030460047C67492840 @default.
• W2030460047 hasConceptScore W2030460047C67705224 @default.
• W2030460047 hasConceptScore W2030460047C70721500 @default.
• W2030460047 hasConceptScore W2030460047C86803240 @default.
• W2030460047 hasIssue "1" @default.
• W2030460047 hasLocation W20304600471 @default.
• W2030460047 hasLocation W20304600472 @default.
• W2030460047 hasLocation W20304600473 @default.

• next