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- W2030463394 abstract "Recent reports on the misuse of β2-agonists, both as stimulants and as “anabolic agents” in sports, highlight the importance of screening and confirmation methods for these compounds in anti-doping control procedures. Although only a few analytical methods have been developed for this purpose, the large experience gained, both in pharmacokinetic studies and above all in the control of the residues of β2-agonists in animal fluids and tissues, can be of great help in the anti-doping field. This paper reviews single-residue (SR) and multi-residue (MR) methods developed for the analysis of β2-agonists in urine, plasma and hair samples, based on hyphenated chromatographic and mass spectrometric techniques, published in the last ten-year period. The evolution from GC-MS analysis after derivatization, with particular attention to the features of different proposed derivatives, to the most recent applications of coupled-column liquid chromatography (LC-LC) combined with tandem mass spectrometric detection (MS-MS) via a thermospray (TSP) interface is illustrated, and future perspectives in the field are outlined." @default.
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- W2030463394 date "1996-12-01" @default.
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- W2030463394 title "Bioanalysis of β2-agonists by hyphenated chromatographic and mass spectrometric techniques" @default.
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- W2030463394 doi "https://doi.org/10.1016/s0378-4347(96)00015-1" @default.
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