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• W2030481412 endingPage "310" @default.
• W2030481412 startingPage "301" @default.
• W2030481412 abstract "Yeast has proven to be a very useful model organism for studying eukaryotic cell functions. Its applicability for population and quantitative genetics is less well known. Among its advantages is the ease of screening for mutants. The present paper reviews experiments aimed at estimating the parameters of spontaneous mutations deleterious to fitness. The rate of deleterious mutation was found to be moderately high. A large fraction of detectable mutants were lethal; among the non-lethal mutants, the least harmful ones dominated. Deleterious mutations, and especially the lethal ones, were generally very well masked by wild-type alleles when in heterozygous loci. The negative effects of mutations were much stronger under stressful than under benign conditions. Interactions between loci with deleterious mutations did alter their fitness, but no strong overall effect of synergism or antagonisms was observed." @default.
• W2030481412 created "2016-06-24" @default.
• W2030481412 creator A5036552437 @default.
• W2030481412 date "2004-06-01" @default.
• W2030481412 modified "2023-10-17" @default.
• W2030481412 title "Experimental studies of deleterious mutation in Saccharomyces cerevisiae" @default.
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• W2030481412 doi "https://doi.org/10.1016/j.resmic.2004.01.015" @default.
• W2030481412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15207861" @default.
• W2030481412 hasPublicationYear "2004" @default.
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