Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030483280> ?p ?o ?g. }
- W2030483280 endingPage "342" @default.
- W2030483280 startingPage "332" @default.
- W2030483280 abstract "The organization of the eukaryotic genome into chromatin enables DNA to fit inside the nucleus while also regulating the access of proteins to the DNA to facilitate genomic functions such as transcription, replication and repair. The basic repeating unit of chromatin is the nucleosome, which includes 147 bp of DNA wrapped 1.65 times around an octamer of core histone proteins comprising two molecules each of H2A, H2B, H3 and H4 [1]. Each nucleosome is a highly stable unit, being maintained by over 120 direct protein–DNA interactions and several hundred water mediated ones [1]. Accordingly, there is considerable interest in understanding how processive enzymes such as RNA polymerases manage to pass along the coding regions of our genes that are tightly packaged into arrays of nucleosomes. Here we present the current mechanistic understanding of this process and the evidence for profound changes in chromatin dynamics during aging. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly." @default.
- W2030483280 created "2016-06-24" @default.
- W2030483280 creator A5042369850 @default.
- W2030483280 creator A5079176198 @default.
- W2030483280 date "2012-03-01" @default.
- W2030483280 modified "2023-09-27" @default.
- W2030483280 title "Histone exchange and histone modifications during transcription and aging" @default.
- W2030483280 cites W1586131224 @default.
- W2030483280 cites W1586705837 @default.
- W2030483280 cites W1918957812 @default.
- W2030483280 cites W1952811255 @default.
- W2030483280 cites W1965469784 @default.
- W2030483280 cites W1965767695 @default.
- W2030483280 cites W1966667302 @default.
- W2030483280 cites W1968574234 @default.
- W2030483280 cites W1969543649 @default.
- W2030483280 cites W1970748830 @default.
- W2030483280 cites W1970916644 @default.
- W2030483280 cites W1972449952 @default.
- W2030483280 cites W1976736157 @default.
- W2030483280 cites W1977434752 @default.
- W2030483280 cites W1979245454 @default.
- W2030483280 cites W1980716967 @default.
- W2030483280 cites W1990955843 @default.
- W2030483280 cites W1991045672 @default.
- W2030483280 cites W1994380035 @default.
- W2030483280 cites W1996270170 @default.
- W2030483280 cites W2000342325 @default.
- W2030483280 cites W2000777709 @default.
- W2030483280 cites W2005793722 @default.
- W2030483280 cites W2006124206 @default.
- W2030483280 cites W2008543992 @default.
- W2030483280 cites W2014179038 @default.
- W2030483280 cites W2017117976 @default.
- W2030483280 cites W2018060941 @default.
- W2030483280 cites W2020363034 @default.
- W2030483280 cites W2020763705 @default.
- W2030483280 cites W2024494581 @default.
- W2030483280 cites W2027788169 @default.
- W2030483280 cites W2029388127 @default.
- W2030483280 cites W2029601224 @default.
- W2030483280 cites W2031156443 @default.
- W2030483280 cites W2036166114 @default.
- W2030483280 cites W2037589637 @default.
- W2030483280 cites W2040327353 @default.
- W2030483280 cites W2042576491 @default.
- W2030483280 cites W2046306550 @default.
- W2030483280 cites W2047156847 @default.
- W2030483280 cites W2052130151 @default.
- W2030483280 cites W2052169804 @default.
- W2030483280 cites W2053895090 @default.
- W2030483280 cites W2054589275 @default.
- W2030483280 cites W2062947816 @default.
- W2030483280 cites W2062986387 @default.
- W2030483280 cites W2064340284 @default.
- W2030483280 cites W2066962210 @default.
- W2030483280 cites W2067651011 @default.
- W2030483280 cites W2068300851 @default.
- W2030483280 cites W2069328568 @default.
- W2030483280 cites W2070994087 @default.
- W2030483280 cites W2072810104 @default.
- W2030483280 cites W2074589964 @default.
- W2030483280 cites W2075213209 @default.
- W2030483280 cites W2077420823 @default.
- W2030483280 cites W2078003979 @default.
- W2030483280 cites W2078281194 @default.
- W2030483280 cites W2081585031 @default.
- W2030483280 cites W2081864633 @default.
- W2030483280 cites W2082623015 @default.
- W2030483280 cites W2084396631 @default.
- W2030483280 cites W2084688823 @default.
- W2030483280 cites W2085759022 @default.
- W2030483280 cites W2086188832 @default.
- W2030483280 cites W2086473824 @default.
- W2030483280 cites W2086877549 @default.
- W2030483280 cites W2087573417 @default.
- W2030483280 cites W2088778716 @default.
- W2030483280 cites W2088853419 @default.
- W2030483280 cites W2091741398 @default.
- W2030483280 cites W2101012764 @default.
- W2030483280 cites W2103263994 @default.
- W2030483280 cites W2106257666 @default.
- W2030483280 cites W2112994680 @default.
- W2030483280 cites W2118134867 @default.
- W2030483280 cites W2123491442 @default.
- W2030483280 cites W2123543932 @default.
- W2030483280 cites W2127079829 @default.
- W2030483280 cites W2128507162 @default.
- W2030483280 cites W2129068490 @default.
- W2030483280 cites W2130217132 @default.
- W2030483280 cites W2133063603 @default.
- W2030483280 cites W2133233872 @default.
- W2030483280 cites W2137364646 @default.
- W2030483280 cites W2143351999 @default.
- W2030483280 cites W2144792857 @default.
- W2030483280 cites W2146728902 @default.
- W2030483280 cites W2153154881 @default.
- W2030483280 cites W2154240028 @default.