FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030484782> ?p ?o ?g. }

• W2030484782 endingPage "988" @default.
• W2030484782 startingPage "979" @default.
• W2030484782 abstract "The corticosteroid hormone induced factor (CHIF) is a member of the one-transmembrane segment protein family named FXYD, which also counts phospholemman and the Na,K-pump gamma-subunit. Originally it was suggested that CHIF could induce the expression of the I(Ks) current when expressed in Xenopus laevis oocytes, but recently CHIF has attracted attention as a modulatory subunit of the Na,K-pump. In renal and intestinal epithelia, the expression of CHIF is dramatically up-regulated in response to aldosterone stimulation, and regulation of epithelial ion channels by CHIF is an attractive hypothesis. To study a potential regulatory effect of the CHIF subunit on KCNQ1 channels, co-expression experiments were performed in Xenopus laevis oocytes and mammalian CHO-K1 cells. Electrophysiological characterization was obtained by two-electrode voltage-clamp and patch-clamp, respectively. In both expression systems, we find that CHIF drastically modulates the KCNQ1 current; in the presence of CHIF, the KCNQ1 channels open at all membrane potentials. Thereby, CHIF is the first accessory subunit shown to be capable of modulating both the Na,K-pump and an ion channel. To find a possible physiological function of the constitutively open KCNQ1/CHIF complex, the precise localization of KCNQ1 and CHIF in distal colon and kidney from control and salt-depleted rats was determined by confocal microscopy. However, in these tissues, we did not detect an obvious overlap in expression between KCNQ1 and CHIF. In conclusion, the hormone-regulated subunit CHIF modulates the voltage sensitivity of the KCNQ channels, but so far evidence for an actual co-localization of CHIF and KCNQ1 channels in native tissue is lacking." @default.
• W2030484782 created "2016-06-24" @default.
• W2030484782 creator A5039252979 @default.
• W2030484782 creator A5039588653 @default.
• W2030484782 creator A5046929786 @default.
• W2030484782 creator A5071825449 @default.
• W2030484782 creator A5073616733 @default.
• W2030484782 creator A5074300840 @default.
• W2030484782 creator A5076957580 @default.
• W2030484782 creator A5085159054 @default.
• W2030484782 date "2006-03-01" @default.
• W2030484782 modified "2023-09-27" @default.
• W2030484782 title "The corticosteroid hormone induced factor: A new modulator of KCNQ1 channels?" @default.
• W2030484782 cites W142444126 @default.
• W2030484782 cites W1606565754 @default.
• W2030484782 cites W1668163968 @default.
• W2030484782 cites W1905377350 @default.
• W2030484782 cites W1944281814 @default.
• W2030484782 cites W1955684338 @default.
• W2030484782 cites W1964210830 @default.
• W2030484782 cites W1979005514 @default.
• W2030484782 cites W1980205307 @default.
• W2030484782 cites W1983137097 @default.
• W2030484782 cites W1987598264 @default.
• W2030484782 cites W1991662012 @default.
• W2030484782 cites W1993651887 @default.
• W2030484782 cites W1994783344 @default.
• W2030484782 cites W1994983075 @default.
• W2030484782 cites W2001439421 @default.
• W2030484782 cites W2002422701 @default.
• W2030484782 cites W2005671393 @default.
• W2030484782 cites W2013281087 @default.
• W2030484782 cites W2024647359 @default.
• W2030484782 cites W2025346950 @default.
• W2030484782 cites W2025398141 @default.
• W2030484782 cites W2035668312 @default.
• W2030484782 cites W2040081725 @default.
• W2030484782 cites W2047142749 @default.
• W2030484782 cites W2059995944 @default.
• W2030484782 cites W2068748822 @default.
• W2030484782 cites W2069847823 @default.
• W2030484782 cites W2069886131 @default.
• W2030484782 cites W2085382664 @default.
• W2030484782 cites W2101310027 @default.
• W2030484782 cites W2102650234 @default.
• W2030484782 cites W2104605409 @default.
• W2030484782 cites W2126590887 @default.
• W2030484782 cites W2136418884 @default.
• W2030484782 cites W2136579499 @default.
• W2030484782 cites W2147580778 @default.
• W2030484782 cites W2158465267 @default.
• W2030484782 cites W2161453230 @default.
• W2030484782 cites W2467226354 @default.
• W2030484782 cites W4251984461 @default.
• W2030484782 doi "https://doi.org/10.1016/j.bbrc.2006.01.046" @default.
• W2030484782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16476578" @default.
• W2030484782 hasPublicationYear "2006" @default.
• W2030484782 type Work @default.
• W2030484782 sameAs 2030484782 @default.
• W2030484782 citedByCount "12" @default.
• W2030484782 countsByYear W20304847822013 @default.
• W2030484782 countsByYear W20304847822016 @default.
• W2030484782 countsByYear W20304847822020 @default.
• W2030484782 countsByYear W20304847822022 @default.
• W2030484782 crossrefType "journal-article" @default.
• W2030484782 hasAuthorship W2030484782A5039252979 @default.
• W2030484782 hasAuthorship W2030484782A5039588653 @default.
• W2030484782 hasAuthorship W2030484782A5046929786 @default.
• W2030484782 hasAuthorship W2030484782A5071825449 @default.
• W2030484782 hasAuthorship W2030484782A5073616733 @default.
• W2030484782 hasAuthorship W2030484782A5074300840 @default.
• W2030484782 hasAuthorship W2030484782A5076957580 @default.
• W2030484782 hasAuthorship W2030484782A5085159054 @default.
• W2030484782 hasConcept C100837961 @default.
• W2030484782 hasConcept C104292427 @default.
• W2030484782 hasConcept C104317684 @default.
• W2030484782 hasConcept C12554922 @default.
• W2030484782 hasConcept C126322002 @default.
• W2030484782 hasConcept C134018914 @default.
• W2030484782 hasConcept C147944092 @default.
• W2030484782 hasConcept C169760540 @default.
• W2030484782 hasConcept C170493617 @default.
• W2030484782 hasConcept C181911157 @default.
• W2030484782 hasConcept C185263204 @default.
• W2030484782 hasConcept C185592680 @default.
• W2030484782 hasConcept C2778525890 @default.
• W2030484782 hasConcept C2779535977 @default.
• W2030484782 hasConcept C50254741 @default.
• W2030484782 hasConcept C55493867 @default.
• W2030484782 hasConcept C71924100 @default.
• W2030484782 hasConcept C86803240 @default.
• W2030484782 hasConcept C95444343 @default.
• W2030484782 hasConceptScore W2030484782C100837961 @default.
• W2030484782 hasConceptScore W2030484782C104292427 @default.
• W2030484782 hasConceptScore W2030484782C104317684 @default.
• W2030484782 hasConceptScore W2030484782C12554922 @default.
• W2030484782 hasConceptScore W2030484782C126322002 @default.
• W2030484782 hasConceptScore W2030484782C134018914 @default.

• next