Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030484867> ?p ?o ?g. }
- W2030484867 endingPage "20596" @default.
- W2030484867 startingPage "20591" @default.
- W2030484867 abstract "The exchange of substances between higher organisms and the environment occurs across transporting epithelia whose basic features are tight junctions (TJs) that seal the intercellular space, and polarity, which enables cells to transport substances vectorially. In a previous study, we demonstrated that 10 nM ouabain modulates TJs, and we now show that it controls polarity as well. We gauge polarity through the development of a cilium at the apical domain of Madin-Darby canine kidney cells (MDCK, epithelial dog kidney). Ouabain accelerates ciliogenesis in an ERK1/2-dependent manner. Claudin-2, a molecule responsible for the Na + and H 2 O permeability of the TJs, is also present at the cilium, as it colocalizes and coprecipitates with acetylated α-tubulin. Ouabain modulates claudin-2 localization at the cilium through ERK1/2. Comparing wild-type and ouabain-resistant MDCK cells, we show that ouabain acts through Na + ,K + -ATPase. Taken together, our previous and present results support the possibility that ouabain constitutes a hormone that modulates the transporting epithelial phenotype, thereby playing a crucial role in metazoan life." @default.
- W2030484867 created "2016-06-24" @default.
- W2030484867 creator A5000227280 @default.
- W2030484867 creator A5005282829 @default.
- W2030484867 creator A5007421361 @default.
- W2030484867 creator A5014176621 @default.
- W2030484867 creator A5025863692 @default.
- W2030484867 creator A5033323668 @default.
- W2030484867 creator A5036721671 @default.
- W2030484867 date "2011-12-05" @default.
- W2030484867 modified "2023-10-14" @default.
- W2030484867 title "Ouabain modulates ciliogenesis in epithelial cells" @default.
- W2030484867 cites W1508102251 @default.
- W2030484867 cites W1536844713 @default.
- W2030484867 cites W1607664237 @default.
- W2030484867 cites W1970260922 @default.
- W2030484867 cites W1976839673 @default.
- W2030484867 cites W1984687894 @default.
- W2030484867 cites W1989397082 @default.
- W2030484867 cites W1996613222 @default.
- W2030484867 cites W2002299808 @default.
- W2030484867 cites W2006418289 @default.
- W2030484867 cites W2008049480 @default.
- W2030484867 cites W2009455555 @default.
- W2030484867 cites W2018893188 @default.
- W2030484867 cites W2025613625 @default.
- W2030484867 cites W2041508753 @default.
- W2030484867 cites W2045035724 @default.
- W2030484867 cites W2047902407 @default.
- W2030484867 cites W2051523425 @default.
- W2030484867 cites W2055211442 @default.
- W2030484867 cites W2074458710 @default.
- W2030484867 cites W2077266233 @default.
- W2030484867 cites W2081787890 @default.
- W2030484867 cites W2083227988 @default.
- W2030484867 cites W2083448771 @default.
- W2030484867 cites W2088130063 @default.
- W2030484867 cites W2095649385 @default.
- W2030484867 cites W2097281794 @default.
- W2030484867 cites W2097814316 @default.
- W2030484867 cites W2119379108 @default.
- W2030484867 cites W2121034044 @default.
- W2030484867 cites W2121473111 @default.
- W2030484867 cites W2127518700 @default.
- W2030484867 cites W2130400575 @default.
- W2030484867 cites W2134189925 @default.
- W2030484867 cites W2147118691 @default.
- W2030484867 cites W2151659832 @default.
- W2030484867 cites W2154377445 @default.
- W2030484867 cites W2162293943 @default.
- W2030484867 cites W2163616625 @default.
- W2030484867 cites W2171950662 @default.
- W2030484867 cites W2199888716 @default.
- W2030484867 cites W2283470641 @default.
- W2030484867 doi "https://doi.org/10.1073/pnas.1102617108" @default.
- W2030484867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3251114" @default.
- W2030484867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22143774" @default.
- W2030484867 hasPublicationYear "2011" @default.
- W2030484867 type Work @default.
- W2030484867 sameAs 2030484867 @default.
- W2030484867 citedByCount "31" @default.
- W2030484867 countsByYear W20304848672012 @default.
- W2030484867 countsByYear W20304848672013 @default.
- W2030484867 countsByYear W20304848672014 @default.
- W2030484867 countsByYear W20304848672015 @default.
- W2030484867 countsByYear W20304848672016 @default.
- W2030484867 countsByYear W20304848672017 @default.
- W2030484867 countsByYear W20304848672019 @default.
- W2030484867 countsByYear W20304848672020 @default.
- W2030484867 countsByYear W20304848672021 @default.
- W2030484867 countsByYear W20304848672022 @default.
- W2030484867 countsByYear W20304848672023 @default.
- W2030484867 crossrefType "journal-article" @default.
- W2030484867 hasAuthorship W2030484867A5000227280 @default.
- W2030484867 hasAuthorship W2030484867A5005282829 @default.
- W2030484867 hasAuthorship W2030484867A5007421361 @default.
- W2030484867 hasAuthorship W2030484867A5014176621 @default.
- W2030484867 hasAuthorship W2030484867A5025863692 @default.
- W2030484867 hasAuthorship W2030484867A5033323668 @default.
- W2030484867 hasAuthorship W2030484867A5036721671 @default.
- W2030484867 hasBestOaLocation W20304848671 @default.
- W2030484867 hasConcept C100094513 @default.
- W2030484867 hasConcept C1491633281 @default.
- W2030484867 hasConcept C177779419 @default.
- W2030484867 hasConcept C178790620 @default.
- W2030484867 hasConcept C185592680 @default.
- W2030484867 hasConcept C195267511 @default.
- W2030484867 hasConcept C2777361361 @default.
- W2030484867 hasConcept C2779133857 @default.
- W2030484867 hasConcept C39587587 @default.
- W2030484867 hasConcept C49353375 @default.
- W2030484867 hasConcept C537181965 @default.
- W2030484867 hasConcept C55493867 @default.
- W2030484867 hasConcept C86803240 @default.
- W2030484867 hasConcept C95444343 @default.
- W2030484867 hasConceptScore W2030484867C100094513 @default.
- W2030484867 hasConceptScore W2030484867C1491633281 @default.
- W2030484867 hasConceptScore W2030484867C177779419 @default.