Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030486864> ?p ?o ?g. }
- W2030486864 endingPage "53" @default.
- W2030486864 startingPage "53" @default.
- W2030486864 abstract "First-line treatment of chronic lymphocytic leukemia: role of alemtuzumab Carmen Diana Schweighofer1, Clemens-Martin Wendtner21Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA; 2Department of Internal Medicine I, University of Cologne, Cologne, GermanyAbstract: The CD52-targeting antibody alemtuzumab is established in clinical practice with convincing activity in relapsed and refractory chronic lymphocytic leukemia (CLL), particularly in patients with high-risk features and adverse prognosis. In the CAM307 study alemtuzumab was tested and finally approved as a first-line single agent, even though the hurdle with chlorambucil as the contender was not set very high. Within clinical trials, the drug demonstrated an excellent ability to eliminate minimal residual disease in blood and bone marrow, which has been correlated with a corresponding survival advantage in patients. However, in the maintenance setting, infectious complications due to severe T cell suppression have been highlighted and do not allow clinicans to use alemtuzumab outside of clinical trials. This review discusses potential therapeutic niches and future applications of alemtuzumab with a focus on CLL front-line treatment.Keywords: CLL, alemtuzumab, Campath, front-line, first-line treatment" @default.
- W2030486864 created "2016-06-24" @default.
- W2030486864 creator A5034764934 @default.
- W2030486864 date "2010-03-01" @default.
- W2030486864 modified "2023-10-16" @default.
- W2030486864 title "First-line treatment of chronic lymphocytic leukemia: role of alemtuzumab" @default.
- W2030486864 cites W1243376384 @default.
- W2030486864 cites W1429374962 @default.
- W2030486864 cites W146673805 @default.
- W2030486864 cites W1833241997 @default.
- W2030486864 cites W1849713130 @default.
- W2030486864 cites W1954038871 @default.
- W2030486864 cites W1968458944 @default.
- W2030486864 cites W1972577971 @default.
- W2030486864 cites W1973810603 @default.
- W2030486864 cites W1977691569 @default.
- W2030486864 cites W1978235999 @default.
- W2030486864 cites W1979748716 @default.
- W2030486864 cites W1987819921 @default.
- W2030486864 cites W1989091670 @default.
- W2030486864 cites W2001829722 @default.
- W2030486864 cites W2001850157 @default.
- W2030486864 cites W2003019957 @default.
- W2030486864 cites W2008542227 @default.
- W2030486864 cites W2010450410 @default.
- W2030486864 cites W2011329410 @default.
- W2030486864 cites W2013558736 @default.
- W2030486864 cites W2017723771 @default.
- W2030486864 cites W2024303920 @default.
- W2030486864 cites W2035984867 @default.
- W2030486864 cites W2041353674 @default.
- W2030486864 cites W2047982141 @default.
- W2030486864 cites W2055349083 @default.
- W2030486864 cites W2061365129 @default.
- W2030486864 cites W2067087822 @default.
- W2030486864 cites W2077294419 @default.
- W2030486864 cites W2079481807 @default.
- W2030486864 cites W2081143563 @default.
- W2030486864 cites W2084177625 @default.
- W2030486864 cites W2084744391 @default.
- W2030486864 cites W2086637735 @default.
- W2030486864 cites W2096036897 @default.
- W2030486864 cites W2097852595 @default.
- W2030486864 cites W2099145932 @default.
- W2030486864 cites W2100660422 @default.
- W2030486864 cites W2102505853 @default.
- W2030486864 cites W2111403010 @default.
- W2030486864 cites W2125134816 @default.
- W2030486864 cites W2126015095 @default.
- W2030486864 cites W2126442701 @default.
- W2030486864 cites W2128343424 @default.
- W2030486864 cites W2129945230 @default.
- W2030486864 cites W2134057518 @default.
- W2030486864 cites W2135270635 @default.
- W2030486864 cites W2135556297 @default.
- W2030486864 cites W2135604149 @default.
- W2030486864 cites W2141778028 @default.
- W2030486864 cites W2142099365 @default.
- W2030486864 cites W2142741025 @default.
- W2030486864 cites W2143749371 @default.
- W2030486864 cites W2148329145 @default.
- W2030486864 cites W2153334574 @default.
- W2030486864 cites W2156824251 @default.
- W2030486864 cites W2157720475 @default.
- W2030486864 cites W2159880472 @default.
- W2030486864 cites W2162125647 @default.
- W2030486864 cites W2163348695 @default.
- W2030486864 cites W2164831445 @default.
- W2030486864 cites W2165346275 @default.
- W2030486864 cites W2169167811 @default.
- W2030486864 cites W2170340332 @default.
- W2030486864 cites W2172245258 @default.
- W2030486864 cites W2317888977 @default.
- W2030486864 cites W2318933236 @default.
- W2030486864 cites W2323490326 @default.
- W2030486864 cites W2326175431 @default.
- W2030486864 cites W2337089158 @default.
- W2030486864 cites W2530849054 @default.
- W2030486864 cites W2547004112 @default.
- W2030486864 cites W2548179571 @default.
- W2030486864 cites W2549604233 @default.
- W2030486864 cites W2553030065 @default.
- W2030486864 cites W2555362824 @default.
- W2030486864 cites W2556992980 @default.
- W2030486864 cites W2559438779 @default.
- W2030486864 cites W2565132879 @default.
- W2030486864 cites W2570092068 @default.
- W2030486864 cites W2583298613 @default.
- W2030486864 cites W2592196653 @default.
- W2030486864 cites W2593970144 @default.
- W2030486864 cites W2979568374 @default.
- W2030486864 cites W2992176882 @default.
- W2030486864 cites W3145158830 @default.
- W2030486864 cites W3183885513 @default.
- W2030486864 cites W60865865 @default.
- W2030486864 cites W83807906 @default.
- W2030486864 cites W85233391 @default.
- W2030486864 cites W2101252134 @default.