FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030487003> ?p ?o ?g. }

• W2030487003 endingPage "e1001347" @default.
• W2030487003 startingPage "e1001347" @default.
• W2030487003 abstract "There is increasing evidence that non-coding macroRNAs are major elements for silencing imprinted genes, but their mechanism of action is poorly understood. Within the imprinted Gnas cluster on mouse chromosome 2, Nespas is a paternally expressed macroRNA that arises from an imprinting control region and runs antisense to Nesp, a paternally repressed protein coding transcript. Here we report a knock-in mouse allele that behaves as a Nespas hypomorph. The hypomorph mediates down-regulation of Nesp in cis through chromatin modification at the Nesp promoter but in the absence of somatic DNA methylation. Notably there is reduced demethylation of H3K4me3, sufficient for down-regulation of Nesp, but insufficient for DNA methylation; in addition, there is depletion of the H3K36me3 mark permissive for DNA methylation. We propose an order of events for the regulation of a somatic imprint on the wild-type allele whereby Nespas modulates demethylation of H3K4me3 resulting in repression of Nesp followed by DNA methylation. This study demonstrates that a non-coding antisense transcript or its transcription is associated with silencing an overlapping protein-coding gene by a mechanism independent of DNA methylation. These results have broad implications for understanding the hierarchy of events in epigenetic silencing by macroRNAs." @default.
• W2030487003 created "2016-06-24" @default.
• W2030487003 creator A5015609268 @default.
• W2030487003 creator A5023215339 @default.
• W2030487003 creator A5034944031 @default.
• W2030487003 creator A5042238057 @default.
• W2030487003 creator A5046811172 @default.
• W2030487003 creator A5050081555 @default.
• W2030487003 creator A5065312750 @default.
• W2030487003 creator A5069224126 @default.
• W2030487003 creator A5081917278 @default.
• W2030487003 creator A5082849097 @default.
• W2030487003 date "2011-03-24" @default.
• W2030487003 modified "2023-10-16" @default.
• W2030487003 title "Uncoupling Antisense-Mediated Silencing and DNA Methylation in the Imprinted Gnas Cluster" @default.
• W2030487003 cites W1557292836 @default.
• W2030487003 cites W1673514954 @default.
• W2030487003 cites W1964789204 @default.
• W2030487003 cites W1976695083 @default.
• W2030487003 cites W1981145285 @default.
• W2030487003 cites W1981354816 @default.
• W2030487003 cites W1992658017 @default.
• W2030487003 cites W1999491723 @default.
• W2030487003 cites W2001206796 @default.
• W2030487003 cites W2002206426 @default.
• W2030487003 cites W2003074882 @default.
• W2030487003 cites W2005643112 @default.
• W2030487003 cites W2007941919 @default.
• W2030487003 cites W2012612933 @default.
• W2030487003 cites W2013152274 @default.
• W2030487003 cites W2014979893 @default.
• W2030487003 cites W2017840637 @default.
• W2030487003 cites W2018304597 @default.
• W2030487003 cites W2018776456 @default.
• W2030487003 cites W2019668620 @default.
• W2030487003 cites W2020670236 @default.
• W2030487003 cites W2030047242 @default.
• W2030487003 cites W2039408641 @default.
• W2030487003 cites W2050109271 @default.
• W2030487003 cites W2051288343 @default.
• W2030487003 cites W2056330045 @default.
• W2030487003 cites W2059592231 @default.
• W2030487003 cites W2064188460 @default.
• W2030487003 cites W2086444514 @default.
• W2030487003 cites W2089417246 @default.
• W2030487003 cites W2096172906 @default.
• W2030487003 cites W2108603029 @default.
• W2030487003 cites W2110797244 @default.
• W2030487003 cites W2111390374 @default.
• W2030487003 cites W2115779097 @default.
• W2030487003 cites W2118008591 @default.
• W2030487003 cites W2118123185 @default.
• W2030487003 cites W2118576398 @default.
• W2030487003 cites W2121082491 @default.
• W2030487003 cites W2129916744 @default.
• W2030487003 cites W2138468802 @default.
• W2030487003 cites W2140777499 @default.
• W2030487003 cites W2151585204 @default.
• W2030487003 cites W2157099671 @default.
• W2030487003 cites W2161464307 @default.
• W2030487003 cites W2163432887 @default.
• W2030487003 cites W2168420558 @default.
• W2030487003 cites W4238656497 @default.
• W2030487003 cites W4378711309 @default.
• W2030487003 doi "https://doi.org/10.1371/journal.pgen.1001347" @default.
• W2030487003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3063750" @default.
• W2030487003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21455290" @default.
• W2030487003 hasPublicationYear "2011" @default.
• W2030487003 type Work @default.
• W2030487003 sameAs 2030487003 @default.
• W2030487003 citedByCount "87" @default.
• W2030487003 countsByYear W20304870032012 @default.
• W2030487003 countsByYear W20304870032013 @default.
• W2030487003 countsByYear W20304870032014 @default.
• W2030487003 countsByYear W20304870032015 @default.
• W2030487003 countsByYear W20304870032016 @default.
• W2030487003 countsByYear W20304870032017 @default.
• W2030487003 countsByYear W20304870032018 @default.
• W2030487003 countsByYear W20304870032019 @default.
• W2030487003 countsByYear W20304870032020 @default.
• W2030487003 countsByYear W20304870032021 @default.
• W2030487003 countsByYear W20304870032022 @default.
• W2030487003 countsByYear W20304870032023 @default.
• W2030487003 crossrefType "journal-article" @default.
• W2030487003 hasAuthorship W2030487003A5015609268 @default.
• W2030487003 hasAuthorship W2030487003A5023215339 @default.
• W2030487003 hasAuthorship W2030487003A5034944031 @default.
• W2030487003 hasAuthorship W2030487003A5042238057 @default.
• W2030487003 hasAuthorship W2030487003A5046811172 @default.
• W2030487003 hasAuthorship W2030487003A5050081555 @default.
• W2030487003 hasAuthorship W2030487003A5065312750 @default.
• W2030487003 hasAuthorship W2030487003A5069224126 @default.
• W2030487003 hasAuthorship W2030487003A5081917278 @default.
• W2030487003 hasAuthorship W2030487003A5082849097 @default.
• W2030487003 hasBestOaLocation W20304870031 @default.
• W2030487003 hasConcept C104317684 @default.
• W2030487003 hasConcept C119056186 @default.
• W2030487003 hasConcept C150194340 @default.

• next