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• W2030492074 abstract "Background and Purpose Neurological injury after cerebral air embolism may be due to thromboinflammatory responses at sites of air-injured endothelium. Because heparin inhibits multiple thromboinflammatory processes, we hypothesized that heparin would decrease neurological impairment after cerebral air embolism. Methods To first establish a dose of air that would cause unequivocal neurological injury, anesthetized New Zealand White rabbits received either 0, 50, 100, or 150 μL/kg of air into the internal carotid artery (n=5 in each group). One hour later, anesthesia was discontinued. Animals were neurologically evaluated at 24 hours with the use of a scale ranging from 0 (normal) to 97 (coma) points. In a subsequent experiment, anesthetized rabbits received either heparin (n=17) or saline (n=15) 5 minutes before air injection (150 μL/kg). Heparin was given as a 200-IU/kg bolus and followed by a constant infusion of 75 IU · kg −1 · h −1 for 2 hours. Equal volumes of saline were given to control rabbits. Two hours later, anesthesia was discontinued. Animals were neurologically evaluated 24 hours after air embolism. Results There was a monotonic relationship between dose of air and severity of neurological impairment at 24 hours ( P =1.1×10 −7 ). Animals receiving 150 μL/kg of air were unequivocally injured (score, 60±16). In the second experiment, heparin animals had significantly less neurological impairment at 24 hours (34±14) than saline controls (52±8) ( P =.0013). Conclusions When given prophylactically, heparin decreases neurological impairment caused by severe cerebral arterial air embolism." @default.
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• W2030492074 date "1996-02-01" @default.
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• W2030492074 title "Heparin Reduces Neurological Impairment After Cerebral Arterial Air Embolism in the Rabbit" @default.
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• W2030492074 doi "https://doi.org/10.1161/01.str.27.2.303" @default.
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