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• W2030528042 startingPage "486" @default.
• W2030528042 abstract "Extraordinary progress has been made in our detailed understanding of the genetic and epigenetic mechanisms responsible for oncogenesis and cancer progression. Empowered by next-generation sequencing, many new targets and pathways have been identified to exploit oncogene and non-oncogene addiction and synthetic lethality. Kinase inhibitors feature strongly in the druggable cancer genome and 19 have been approved in oncology. While survival gains are valuable, drug resistance has emerged as the major challenge. The clonal heterogeneity and evolution of cancers is an intrinsic problem, together with feedback loops, kinase switching and activation of alternative targets and pathways. The solution to drug resistance will require the use of rationally targeted combinational regimens. The application of adaptive treatment cycles based on ongoing multi-technology profiling will be the key to long-term therapeutic success." @default.
• W2030528042 created "2016-06-24" @default.
• W2030528042 creator A5003965204 @default.
• W2030528042 creator A5007910628 @default.
• W2030528042 creator A5042056024 @default.
• W2030528042 date "2013-08-01" @default.
• W2030528042 modified "2023-09-30" @default.
• W2030528042 title "Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology" @default.
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• W2030528042 doi "https://doi.org/10.1016/j.coph.2013.06.004" @default.
• W2030528042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23810823" @default.
• W2030528042 hasPublicationYear "2013" @default.
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