FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030536192> ?p ?o ?g. }

• W2030536192 endingPage "1586" @default.
• W2030536192 startingPage "1581" @default.
• W2030536192 abstract "The effect of the antimalarial drug halofantrine (Hf) on hepatic drug metabolism in the rat has been studied in vivo and in vitro using different model drug substrates. Hf in vitro produced no significant effect on the values of Km and Vmax for aminopyrine N-demethylation or 7-ethoxycoumarin O-dealkylation in microsomes incubated with Hf (0.01-0.1 mM) or on the rate of N-demethylation of aminopyrine or O-dealkylation of Ec in microsomes produced from rats dosed chronically with Hf (200 mg/kg) for 4 days. The disposition of antipyrine (Ap) was investigated in the isolated perfused rat liver preparation (IPRL). Following the administration of bolus doses of Hf (0.5, 2.5 and 5.0 mg) no significant changes were observed in the half-life (t1/2), clearance (Cl) or apparent volume of distribution (Vd) for Ap compared with controls. Pentobarbitone induced sleeping time was also assessed in mice. No significant difference was determined in time to recovery of the righting reflex for mice receiving Hf as single oral doses or chronically over 4 days when compared with appropriate controls. The potential for selective isoenzyme effects was studied in vivo. The three principal urinary metabolites of Ap, norantipyrine (Np), 3-OH and 4-OH Ap were measured in rat urine, with no significant change in urinary recovery of Ap or any of the metabolites in the presence of Hf (1.25 mg/kg i.p.) compared with controls. These results suggest that Hf is not, in contrast to many commonly used quinoline antimalarials, a potent or specific inhibitor of drug metabolism in vitro or in vivo." @default.
• W2030536192 created "2016-06-24" @default.
• W2030536192 creator A5008381642 @default.
• W2030536192 creator A5023525514 @default.
• W2030536192 creator A5046770947 @default.
• W2030536192 creator A5061252066 @default.
• W2030536192 date "1990-05-01" @default.
• W2030536192 modified "2023-09-27" @default.
• W2030536192 title "Lack of effect of halofantrine on hepatic drug metabolism in the rat in vivo and in vitro" @default.
• W2030536192 cites W1775749144 @default.
• W2030536192 cites W1806194750 @default.
• W2030536192 cites W1951469402 @default.
• W2030536192 cites W2002603564 @default.
• W2030536192 cites W2006246928 @default.
• W2030536192 cites W2034258201 @default.
• W2030536192 cites W2041689071 @default.
• W2030536192 cites W2044167737 @default.
• W2030536192 cites W2055738436 @default.
• W2030536192 cites W2063883313 @default.
• W2030536192 cites W2064775950 @default.
• W2030536192 cites W2085986330 @default.
• W2030536192 cites W2090565743 @default.
• W2030536192 cites W2092508738 @default.
• W2030536192 cites W2094447600 @default.
• W2030536192 cites W2105650062 @default.
• W2030536192 doi "https://doi.org/10.1016/0006-2952(90)90524-o" @default.
• W2030536192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2337415" @default.
• W2030536192 hasPublicationYear "1990" @default.
• W2030536192 type Work @default.
• W2030536192 sameAs 2030536192 @default.
• W2030536192 citedByCount "5" @default.
• W2030536192 crossrefType "journal-article" @default.
• W2030536192 hasAuthorship W2030536192A5008381642 @default.
• W2030536192 hasAuthorship W2030536192A5023525514 @default.
• W2030536192 hasAuthorship W2030536192A5046770947 @default.
• W2030536192 hasAuthorship W2030536192A5061252066 @default.
• W2030536192 hasConcept C104317684 @default.
• W2030536192 hasConcept C112705442 @default.
• W2030536192 hasConcept C126322002 @default.
• W2030536192 hasConcept C134018914 @default.
• W2030536192 hasConcept C139254425 @default.
• W2030536192 hasConcept C150194340 @default.
• W2030536192 hasConcept C150903083 @default.
• W2030536192 hasConcept C185592680 @default.
• W2030536192 hasConcept C190727270 @default.
• W2030536192 hasConcept C202199734 @default.
• W2030536192 hasConcept C202751555 @default.
• W2030536192 hasConcept C203014093 @default.
• W2030536192 hasConcept C207001950 @default.
• W2030536192 hasConcept C2777056448 @default.
• W2030536192 hasConcept C2777199930 @default.
• W2030536192 hasConcept C2777425658 @default.
• W2030536192 hasConcept C2777498558 @default.
• W2030536192 hasConcept C2778048844 @default.
• W2030536192 hasConcept C43376680 @default.
• W2030536192 hasConcept C55493867 @default.
• W2030536192 hasConcept C62231903 @default.
• W2030536192 hasConcept C71924100 @default.
• W2030536192 hasConcept C86803240 @default.
• W2030536192 hasConcept C87644729 @default.
• W2030536192 hasConcept C89311334 @default.
• W2030536192 hasConcept C98274493 @default.
• W2030536192 hasConceptScore W2030536192C104317684 @default.
• W2030536192 hasConceptScore W2030536192C112705442 @default.
• W2030536192 hasConceptScore W2030536192C126322002 @default.
• W2030536192 hasConceptScore W2030536192C134018914 @default.
• W2030536192 hasConceptScore W2030536192C139254425 @default.
• W2030536192 hasConceptScore W2030536192C150194340 @default.
• W2030536192 hasConceptScore W2030536192C150903083 @default.
• W2030536192 hasConceptScore W2030536192C185592680 @default.
• W2030536192 hasConceptScore W2030536192C190727270 @default.
• W2030536192 hasConceptScore W2030536192C202199734 @default.
• W2030536192 hasConceptScore W2030536192C202751555 @default.
• W2030536192 hasConceptScore W2030536192C203014093 @default.
• W2030536192 hasConceptScore W2030536192C207001950 @default.
• W2030536192 hasConceptScore W2030536192C2777056448 @default.
• W2030536192 hasConceptScore W2030536192C2777199930 @default.
• W2030536192 hasConceptScore W2030536192C2777425658 @default.
• W2030536192 hasConceptScore W2030536192C2777498558 @default.
• W2030536192 hasConceptScore W2030536192C2778048844 @default.
• W2030536192 hasConceptScore W2030536192C43376680 @default.
• W2030536192 hasConceptScore W2030536192C55493867 @default.
• W2030536192 hasConceptScore W2030536192C62231903 @default.
• W2030536192 hasConceptScore W2030536192C71924100 @default.
• W2030536192 hasConceptScore W2030536192C86803240 @default.
• W2030536192 hasConceptScore W2030536192C87644729 @default.
• W2030536192 hasConceptScore W2030536192C89311334 @default.
• W2030536192 hasConceptScore W2030536192C98274493 @default.
• W2030536192 hasIssue "10" @default.
• W2030536192 hasLocation W20305361921 @default.
• W2030536192 hasLocation W20305361922 @default.
• W2030536192 hasOpenAccess W2030536192 @default.
• W2030536192 hasPrimaryLocation W20305361921 @default.
• W2030536192 hasRelatedWork W1491964893 @default.
• W2030536192 hasRelatedWork W1836477835 @default.
• W2030536192 hasRelatedWork W1967723196 @default.
• W2030536192 hasRelatedWork W2004556784 @default.
• W2030536192 hasRelatedWork W2008995722 @default.

• next