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• W2030548501 abstract "No AccessJournal of UrologyPEDIATRIC UROLOGY: Classic Article in Pediatric Urology1 Aug 2002Histological Findings After Colocystoplasty And Gastrocystoplasty P. Vajda, L. Kaiser, T. Magyarlaki, A. Farkas, A.M. Vastyan, and A.B. Pinter P. VajdaP. Vajda More articles by this author , L. KaiserL. Kaiser More articles by this author , T. MagyarlakiT. Magyarlaki More articles by this author , A. FarkasA. Farkas More articles by this author , A.M. VastyanA.M. Vastyan More articles by this author , and A.B. PinterA.B. Pinter More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64727-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We conducted a prospective, long-term assessment of the histological changes that can occur following bladder augmentation with colon or stomach. Materials and Methods: Histological evaluations of biopsies from 44 consecutive patients undergoing augmentation (colocystoplasty in 26, gastrocystoplasty in 18) were performed. Patients underwent endoscopic assessment and tissue sampling at 2 or 4-year intervals following the initial augmentation procedure. Patients with less than 2 years of followup were excluded from the analysis. Specimens were taken from the native bladder, the augment segment (large bowel or stomach) and the anastomotic line. Sections (4 μ.) were examined using standard histological staining methods (hematoxylin and eosin and periodic acid-Schiff) and immunohistochemistry was performed for different markers of neoplasia, cellular proliferation and blood group antigens. Histological findings were correlated with the incidence of stone formation and urinary tract infection. Results: Group 1 consisted of 20 patients undergoing colocystoplasty who met the criteria for study inclusion. Of the patients 10 (50%) had stones, 19 (95%) had a positive urine culture and 6 had no histological changes. While no cases of malignancy were identified, other forms of pathological change were noted in 14 of the 20 patients (70%). Group 2 included 15 patients undergoing gastrocystoplasty who met the criteria for study inclusion. No stones or malignancy were identified in this group. Positive urine cultures were recorded in 2 patients (13%), no histological changes were found in 6 and 9 (60%) had pathological changes. Conclusions: Periodic prospective biopsy evaluation of children who have undergone either colocystoplasty or gastrocystoplasty failed to reveal any histological evidence of malignancy after 10-year followup. However, histological evidence of a premalignant lesion 13 years after followup suggests that screening for premalignant lesions should be initiated no later than 6 to 10 years following enterocystoplasty. 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Link, Google Scholar From the Departments of Pediatrics, Surgical Unit, Pathology and Clinical Chemistry, University of Pecs, Pecs, Hungary© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byAverch T, Stoffel J, Goldman H, Griebling T, Lerner L, Newman D and Peterson A (2015) AUA White Paper on Catheter Associated Urinary Tract Infections: Definitions and Significance in the Urological PatientUrology Practice, VOL. 2, NO. 6, (321-328), Online publication date: 1-Nov-2015.Higuchi T, Granberg C, Fox J and Husmann D (2010) Augmentation Cystoplasty and Risk of Neoplasia: Fact, Fiction and ControversyJournal of Urology, VOL. 184, NO. 6, (2492-2497), Online publication date: 1-Dec-2010.Vemulakonda V, Lendvay T, Shnorhavorian M, Joyner B, Kaplan H, Mitchell M and Grady R (2008) Metastatic Adenocarcinoma After Augmentation GastrocystoplastyJournal of Urology, VOL. 179, NO. 3, (1094-1097), Online publication date: 1-Mar-2008.Hayashi Y, Yamataka A, Kaneyama K, Kato Y, Lane G and Miyano T (2018) Review of 86 Patients With Myelodysplasia and Neurogenic Bladder Who Underwent Sigmoidocolocystoplasty and Were Followed More Than 10 YearsJournal of Urology, VOL. 176, NO. 4S, (1806-1809), Online publication date: 1-Oct-2006.LIMA S, ARAÚJO L and VILAR F (2018) NONSECRETORY INTESTINOCYSTOPLASTY: A 10-YEAR EXPERIENCEJournal of Urology, VOL. 171, NO. 6 Part 2, (2636-2640), Online publication date: 1-Jun-2004. Volume 168Issue 2August 2002Page: 698-701 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordshistological techniquesurinary tract infectionsurinary diversionbiopsycalculiMetrics Author Information P. Vajda More articles by this author L. Kaiser More articles by this author T. Magyarlaki More articles by this author A. Farkas More articles by this author A.M. Vastyan More articles by this author A.B. Pinter More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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