FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030559251> ?p ?o ?g. }

• W2030559251 endingPage "429" @default.
• W2030559251 startingPage "417" @default.
• W2030559251 abstract "Candida albicans is an opportunistic pathogen that causes fatal disease if the host immunity is compromised. The mortality rate of systemic candidiasis is very high; hence, there is a ceaseless demand for novel pharmaceuticals. In this study, quantitative time-course proteomics of C. albicans during adaptation to fetal bovine serum (FBS) is described. Survival in blood is essential for virulence of C. albicans, and a detailed analysis is required. We cultivated C. albicans in FBS for 0–180 min, and determined quantitative time-course variations of 1024 proteins in the cultured cells by using a LC–MS/MS system with a long monolithic silica capillary column. Clustering analysis identified FBS-induced proteins associated with detoxification of oxidative species, high-affinity glucose transport, citrate cycle, oxidative phosphorylation, and iron acquisition. Furthermore, we identified possible virulence factors such as orf19.4914.1 (named Blood-induced peptide 1, Blp1). Heterologous expression of BLP1 in Saccharomyces cerevisiae shortened the lag phase and resulted in a pleiotropic stress-tolerance phenotype, indicating a possible role for quick adaptation to a stressful environment. While further experiments are necessary to prove virulence of the identified factors, systematic identification of candidate virulence proteins in this study will lead to profound understanding of virulence of C. albicans. This paper describes time-course proteomics of C. albicans during adaptation to serum, which is an essential process for fatal systemic candidiasis. Using a LC–MS/MS system with a monolithic silica capillary column, we have successfully characterized time-course variations of 1024 proteins. Among them, orf19.4914.1 (Blp1) was identified as a novel pleiotropic stress-tolerance peptide, which could have an important role for virulence of C. albicans." @default.
• W2030559251 created "2016-06-24" @default.
• W2030559251 creator A5039809935 @default.
• W2030559251 creator A5042364472 @default.
• W2030559251 creator A5058124517 @default.
• W2030559251 creator A5061409488 @default.
• W2030559251 creator A5063620609 @default.
• W2030559251 creator A5066036279 @default.
• W2030559251 creator A5074040545 @default.
• W2030559251 date "2013-10-01" @default.
• W2030559251 modified "2023-09-27" @default.
• W2030559251 title "Elucidation of potentially virulent factors of Candida albicans during serum adaptation by using quantitative time-course proteomics" @default.
• W2030559251 cites W1969303200 @default.
• W2030559251 cites W1975326829 @default.
• W2030559251 cites W1975511017 @default.
• W2030559251 cites W1976261248 @default.
• W2030559251 cites W1980682226 @default.
• W2030559251 cites W1996789797 @default.
• W2030559251 cites W1999340863 @default.
• W2030559251 cites W2003199362 @default.
• W2030559251 cites W2005393972 @default.
• W2030559251 cites W2006980380 @default.
• W2030559251 cites W2013320349 @default.
• W2030559251 cites W2015012952 @default.
• W2030559251 cites W2016760197 @default.
• W2030559251 cites W2022948162 @default.
• W2030559251 cites W2034700901 @default.
• W2030559251 cites W2035347343 @default.
• W2030559251 cites W2043695427 @default.
• W2030559251 cites W2046300791 @default.
• W2030559251 cites W2053300791 @default.
• W2030559251 cites W2055445260 @default.
• W2030559251 cites W2059884070 @default.
• W2030559251 cites W2064518489 @default.
• W2030559251 cites W2067631595 @default.
• W2030559251 cites W2070265193 @default.
• W2030559251 cites W2075894821 @default.
• W2030559251 cites W2078956740 @default.
• W2030559251 cites W2081292673 @default.
• W2030559251 cites W2082150533 @default.
• W2030559251 cites W2095854759 @default.
• W2030559251 cites W2097795961 @default.
• W2030559251 cites W2098166370 @default.
• W2030559251 cites W2098647152 @default.
• W2030559251 cites W2109228421 @default.
• W2030559251 cites W2112243625 @default.
• W2030559251 cites W2115130703 @default.
• W2030559251 cites W2115881233 @default.
• W2030559251 cites W2117597646 @default.
• W2030559251 cites W2117903782 @default.
• W2030559251 cites W2119468962 @default.
• W2030559251 cites W2120147845 @default.
• W2030559251 cites W2124008198 @default.
• W2030559251 cites W2126421255 @default.
• W2030559251 cites W2128487112 @default.
• W2030559251 cites W2135351988 @default.
• W2030559251 cites W2137959581 @default.
• W2030559251 cites W2140060291 @default.
• W2030559251 cites W2142529984 @default.
• W2030559251 cites W2146920262 @default.
• W2030559251 cites W2149669479 @default.
• W2030559251 cites W2150543962 @default.
• W2030559251 cites W2150616093 @default.
• W2030559251 cites W2151635271 @default.
• W2030559251 cites W2152727338 @default.
• W2030559251 cites W2153104382 @default.
• W2030559251 cites W2153562609 @default.
• W2030559251 cites W2154267551 @default.
• W2030559251 cites W2157594666 @default.
• W2030559251 cites W2159686118 @default.
• W2030559251 cites W2160829255 @default.
• W2030559251 cites W2169540909 @default.
• W2030559251 cites W2170949754 @default.
• W2030559251 cites W2171571929 @default.
• W2030559251 doi "https://doi.org/10.1016/j.jprot.2013.07.031" @default.
• W2030559251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23948566" @default.
• W2030559251 hasPublicationYear "2013" @default.
• W2030559251 type Work @default.
• W2030559251 sameAs 2030559251 @default.
• W2030559251 citedByCount "14" @default.
• W2030559251 countsByYear W20305592512013 @default.
• W2030559251 countsByYear W20305592512014 @default.
• W2030559251 countsByYear W20305592512015 @default.
• W2030559251 countsByYear W20305592512016 @default.
• W2030559251 countsByYear W20305592512017 @default.
• W2030559251 countsByYear W20305592512018 @default.
• W2030559251 countsByYear W20305592512019 @default.
• W2030559251 countsByYear W20305592512020 @default.
• W2030559251 countsByYear W20305592512021 @default.
• W2030559251 countsByYear W20305592512022 @default.
• W2030559251 crossrefType "journal-article" @default.
• W2030559251 hasAuthorship W2030559251A5039809935 @default.
• W2030559251 hasAuthorship W2030559251A5042364472 @default.
• W2030559251 hasAuthorship W2030559251A5058124517 @default.
• W2030559251 hasAuthorship W2030559251A5061409488 @default.
• W2030559251 hasAuthorship W2030559251A5063620609 @default.
• W2030559251 hasAuthorship W2030559251A5066036279 @default.
• W2030559251 hasAuthorship W2030559251A5074040545 @default.

• next