Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030560521> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2030560521 endingPage "156" @default.
- W2030560521 startingPage "147" @default.
- W2030560521 abstract "K(ATP) channels are composed of pore-forming subunits Kir6.x and auxiliary subunits SURx. These channels play important roles in modulating the contractility of vascular smooth muscle cells (SMCs) by altering membrane potentials. The molecular basis of K(ATP) channels in vascular SMCs is unclear and the expression of different K(ATP) channel subunits at protein level in various tissues still undetermined. In this study, using an anti-Kir6.1 antibody, we detected the expression of Kir6.1 proteins in rat vascular tissues including mesenteric artery, pulmonary artery, aorta, and tail artery. Kir6.1 proteins were also identified in heart and other non-vascular tissues including spleen and brain, but they were undetectable in liver and kidney. Immunocytochemical study revealed the expression of Kir6.1 proteins in cultured rat thoracic aortic SMCs. Using the whole-cell patch-clamp technique, it was found that the intracellularly applied anti-Kir6.1 antibody significantly inhibited K(ATP) channel currents in HEK-293 cells that were stably transfected with Kir6.1 cDNA. A better understanding of differential expression of Kir6.1 proteins in various vascular and non-vascular tissues may help discern different molecular basis and functions of K(ATP) channel complexes in these tissues." @default.
- W2030560521 created "2016-06-24" @default.
- W2030560521 creator A5000788770 @default.
- W2030560521 creator A5007660396 @default.
- W2030560521 creator A5015959602 @default.
- W2030560521 creator A5043861758 @default.
- W2030560521 creator A5044787970 @default.
- W2030560521 creator A5052730043 @default.
- W2030560521 date "2004-01-01" @default.
- W2030560521 modified "2023-10-15" @default.
- W2030560521 title "Selective expression of Kir6.1 protein in different vascular and non-vascular tissues" @default.
- W2030560521 cites W1969388350 @default.
- W2030560521 cites W1972400285 @default.
- W2030560521 cites W1979101316 @default.
- W2030560521 cites W1995176377 @default.
- W2030560521 cites W1995543213 @default.
- W2030560521 cites W1995589371 @default.
- W2030560521 cites W2002756207 @default.
- W2030560521 cites W2007017507 @default.
- W2030560521 cites W2010346412 @default.
- W2030560521 cites W2012181178 @default.
- W2030560521 cites W2026086645 @default.
- W2030560521 cites W2031633258 @default.
- W2030560521 cites W2050099786 @default.
- W2030560521 cites W2055502742 @default.
- W2030560521 cites W2056283223 @default.
- W2030560521 cites W2061988480 @default.
- W2030560521 cites W2062305966 @default.
- W2030560521 cites W2073629722 @default.
- W2030560521 cites W2076371060 @default.
- W2030560521 cites W2092941200 @default.
- W2030560521 cites W2115950268 @default.
- W2030560521 cites W2150353959 @default.
- W2030560521 cites W2166610424 @default.
- W2030560521 cites W2504414049 @default.
- W2030560521 doi "https://doi.org/10.1016/j.bcp.2003.08.041" @default.
- W2030560521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14667937" @default.
- W2030560521 hasPublicationYear "2004" @default.
- W2030560521 type Work @default.
- W2030560521 sameAs 2030560521 @default.
- W2030560521 citedByCount "32" @default.
- W2030560521 countsByYear W20305605212012 @default.
- W2030560521 countsByYear W20305605212013 @default.
- W2030560521 countsByYear W20305605212018 @default.
- W2030560521 countsByYear W20305605212019 @default.
- W2030560521 crossrefType "journal-article" @default.
- W2030560521 hasAuthorship W2030560521A5000788770 @default.
- W2030560521 hasAuthorship W2030560521A5007660396 @default.
- W2030560521 hasAuthorship W2030560521A5015959602 @default.
- W2030560521 hasAuthorship W2030560521A5043861758 @default.
- W2030560521 hasAuthorship W2030560521A5044787970 @default.
- W2030560521 hasAuthorship W2030560521A5052730043 @default.
- W2030560521 hasConcept C104317684 @default.
- W2030560521 hasConcept C105702510 @default.
- W2030560521 hasConcept C134018914 @default.
- W2030560521 hasConcept C153911025 @default.
- W2030560521 hasConcept C174510640 @default.
- W2030560521 hasConcept C187882448 @default.
- W2030560521 hasConcept C2779395532 @default.
- W2030560521 hasConcept C2992686903 @default.
- W2030560521 hasConcept C54009773 @default.
- W2030560521 hasConcept C55493867 @default.
- W2030560521 hasConcept C83743174 @default.
- W2030560521 hasConcept C86803240 @default.
- W2030560521 hasConcept C95444343 @default.
- W2030560521 hasConceptScore W2030560521C104317684 @default.
- W2030560521 hasConceptScore W2030560521C105702510 @default.
- W2030560521 hasConceptScore W2030560521C134018914 @default.
- W2030560521 hasConceptScore W2030560521C153911025 @default.
- W2030560521 hasConceptScore W2030560521C174510640 @default.
- W2030560521 hasConceptScore W2030560521C187882448 @default.
- W2030560521 hasConceptScore W2030560521C2779395532 @default.
- W2030560521 hasConceptScore W2030560521C2992686903 @default.
- W2030560521 hasConceptScore W2030560521C54009773 @default.
- W2030560521 hasConceptScore W2030560521C55493867 @default.
- W2030560521 hasConceptScore W2030560521C83743174 @default.
- W2030560521 hasConceptScore W2030560521C86803240 @default.
- W2030560521 hasConceptScore W2030560521C95444343 @default.
- W2030560521 hasIssue "1" @default.
- W2030560521 hasLocation W20305605211 @default.
- W2030560521 hasLocation W20305605212 @default.
- W2030560521 hasOpenAccess W2030560521 @default.
- W2030560521 hasPrimaryLocation W20305605211 @default.
- W2030560521 hasRelatedWork W2077615126 @default.
- W2030560521 hasRelatedWork W2138721420 @default.
- W2030560521 hasRelatedWork W2354393567 @default.
- W2030560521 hasRelatedWork W2372521113 @default.
- W2030560521 hasRelatedWork W2374919108 @default.
- W2030560521 hasRelatedWork W2386445198 @default.
- W2030560521 hasRelatedWork W2389860412 @default.
- W2030560521 hasRelatedWork W2989893422 @default.
- W2030560521 hasRelatedWork W4210672545 @default.
- W2030560521 hasRelatedWork W4238547686 @default.
- W2030560521 hasVolume "67" @default.
- W2030560521 isParatext "false" @default.
- W2030560521 isRetracted "false" @default.
- W2030560521 magId "2030560521" @default.
- W2030560521 workType "article" @default.