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• W2030587046 abstract "<h3>Objective</h3> To determine whether warfarin-treated patients with an international normalized ratio less than 1.7 who receive intravenous tissue plasminogen activator for acute ischemic stroke are at increased risk for symptomatic intracerebral hemorrhage. <h3>Design</h3> Retrospective study. <h3>Setting</h3> Academic hospital. <h3>Patients</h3> Consecutive patients with acute ischemic stroke who are treated with intravenous tissue plasminogen activator. <h3>Main Outcome Measure</h3> Symptomatic intracerebral hemorrhage. <h3>Results</h3> One hundred seven patients were included (mean age, 69.2 years; 43.9% men; median National Institutes of Health Stroke Scale score, 14; median onset-to-treatment time, 140 minutes; baseline warfarin use, 12.1%). The median international normalized ratio was 1.04 (range, 0.82-1.61). The overall rate of symptomatic intracerebral hemorrhage was 6.5%, but it was nearly 10-fold higher among patients taking warfarin compared with those not taking warfarin at baseline (30.8% vs 3.2%, respectively;<i>P</i> = .004). Baseline warfarin use remained strongly associated with symptomatic intracerebral hemorrhage (<i>P</i> = .004) after adjusting for relevant covariates, including age, atrial fibrillation, National Institutes of Health Stroke Scale score, and international normalized ratio. <h3>Conclusions</h3> Despite an international normalized ratio less than 1.7, warfarin-treated patients are more likely than those not taking warfarin to experience symptomatic intracerebral hemorrhage following treatment with intravenous tissue plasminogen activator. Larger studies in this subgroup are warranted." @default.
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• W2030587046 date "2010-05-01" @default.
• W2030587046 modified "2023-09-23" @default.
• W2030587046 title "Symptomatic Intracerebral Hemorrhage Among Eligible Warfarin-Treated Patients Receiving Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke" @default.
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• W2030587046 doi "https://doi.org/10.1001/archneurol.2010.25" @default.
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