FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030590548> ?p ?o ?g. }

• W2030590548 endingPage "422" @default.
• W2030590548 startingPage "416" @default.
• W2030590548 abstract "Bone and lung involvement are two major causes of morbidity in Gaucher disease (GD). The soluble form of CD163 (sCD163) is a valuable diagnostic biomarker for monitoring diseases with increased macrophage activation. We determined sCD163 levels in 30 children and adolescence with GD compared with 30 healthy controls and assessed the relation to phenotypes, disease severity and complications.Thirty GD patients (10 had type 1 and 20 had type 3) were studied stressing on skeletal, pulmonary or neurological manifestations, enzyme replacement therapy (ERT), hematological profile, plasma chitotriosidase activity, D-dimer and sCD163. Liver and spleen volumes and bone mineral density (BMD) were assessed.sCD163 levels were markedly elevated in patients compared with controls. D-dimer, chitotriosidase activity and sCD163 levels were significantly increased in type 3 GD patients compared with type 1. sCD163 was significantly elevated in GD patients with dysphagia, developmental delay, pulmonary hypertension risk or abnormal BMD (osteopenia/osteoporosis) than those without. GD patients receiving ERT every 2weeks had lower levels than those under ERT for more than 2weeks. sCD163 was positively correlated with age, disease duration, severity score index, D-dimer and chitotriosidase activity. The cutoff value of sCD163 at 9400ng/mL could differentiate GD patients with and without pulmonary hypertension risk with a sensitivity of 90% and specificity of 95%.sCD163 is a biomarker for the clinical assessment of macrophage proliferation and activity that would help in risk prediction of bone and lung involvement and monitoring treatment response." @default.
• W2030590548 created "2016-06-24" @default.
• W2030590548 creator A5025725556 @default.
• W2030590548 creator A5042950878 @default.
• W2030590548 creator A5067534533 @default.
• W2030590548 date "2015-02-01" @default.
• W2030590548 modified "2023-10-13" @default.
• W2030590548 title "Macrophage-derived soluble CD163 level in young patients with Gaucher disease: Relation to phenotypes, disease severity and complications" @default.
• W2030590548 cites W1592147357 @default.
• W2030590548 cites W176492470 @default.
• W2030590548 cites W1831130622 @default.
• W2030590548 cites W1970279057 @default.
• W2030590548 cites W1976799894 @default.
• W2030590548 cites W1985723103 @default.
• W2030590548 cites W1986092780 @default.
• W2030590548 cites W1992646508 @default.
• W2030590548 cites W1995536499 @default.
• W2030590548 cites W1997747489 @default.
• W2030590548 cites W2011280194 @default.
• W2030590548 cites W2023285558 @default.
• W2030590548 cites W2027391458 @default.
• W2030590548 cites W2034494850 @default.
• W2030590548 cites W2040695321 @default.
• W2030590548 cites W2047161460 @default.
• W2030590548 cites W2047317922 @default.
• W2030590548 cites W2053490488 @default.
• W2030590548 cites W2065284764 @default.
• W2030590548 cites W2066066517 @default.
• W2030590548 cites W2071546599 @default.
• W2030590548 cites W2077868231 @default.
• W2030590548 cites W2078097676 @default.
• W2030590548 cites W2078657666 @default.
• W2030590548 cites W2079708079 @default.
• W2030590548 cites W2086672639 @default.
• W2030590548 cites W2087290508 @default.
• W2030590548 cites W2089919417 @default.
• W2030590548 cites W2097813811 @default.
• W2030590548 cites W2108283987 @default.
• W2030590548 cites W2114362599 @default.
• W2030590548 cites W2117343295 @default.
• W2030590548 cites W2120097445 @default.
• W2030590548 cites W2143301220 @default.
• W2030590548 cites W2144456776 @default.
• W2030590548 cites W2144618924 @default.
• W2030590548 cites W2146298104 @default.
• W2030590548 cites W2147062533 @default.
• W2030590548 cites W2152713201 @default.
• W2030590548 cites W2165524553 @default.
• W2030590548 cites W2169963174 @default.
• W2030590548 cites W2307104008 @default.
• W2030590548 cites W2323158613 @default.
• W2030590548 cites W4210975044 @default.
• W2030590548 cites W4234282571 @default.
• W2030590548 cites W4255185979 @default.
• W2030590548 doi "https://doi.org/10.1016/j.intimp.2014.12.039" @default.
• W2030590548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25587690" @default.
• W2030590548 hasPublicationYear "2015" @default.
• W2030590548 type Work @default.
• W2030590548 sameAs 2030590548 @default.
• W2030590548 citedByCount "4" @default.
• W2030590548 countsByYear W20305905482016 @default.
• W2030590548 countsByYear W20305905482017 @default.
• W2030590548 crossrefType "journal-article" @default.
• W2030590548 hasAuthorship W2030590548A5025725556 @default.
• W2030590548 hasAuthorship W2030590548A5042950878 @default.
• W2030590548 hasAuthorship W2030590548A5067534533 @default.
• W2030590548 hasConcept C104317684 @default.
• W2030590548 hasConcept C126322002 @default.
• W2030590548 hasConcept C127716648 @default.
• W2030590548 hasConcept C185592680 @default.
• W2030590548 hasConcept C2775858924 @default.
• W2030590548 hasConcept C2776541429 @default.
• W2030590548 hasConcept C2776886416 @default.
• W2030590548 hasConcept C2777083390 @default.
• W2030590548 hasConcept C2779134260 @default.
• W2030590548 hasConcept C2779519742 @default.
• W2030590548 hasConcept C2779969927 @default.
• W2030590548 hasConcept C2780930700 @default.
• W2030590548 hasConcept C2781197716 @default.
• W2030590548 hasConcept C55493867 @default.
• W2030590548 hasConcept C71924100 @default.
• W2030590548 hasConcept C90924648 @default.
• W2030590548 hasConceptScore W2030590548C104317684 @default.
• W2030590548 hasConceptScore W2030590548C126322002 @default.
• W2030590548 hasConceptScore W2030590548C127716648 @default.
• W2030590548 hasConceptScore W2030590548C185592680 @default.
• W2030590548 hasConceptScore W2030590548C2775858924 @default.
• W2030590548 hasConceptScore W2030590548C2776541429 @default.
• W2030590548 hasConceptScore W2030590548C2776886416 @default.
• W2030590548 hasConceptScore W2030590548C2777083390 @default.
• W2030590548 hasConceptScore W2030590548C2779134260 @default.
• W2030590548 hasConceptScore W2030590548C2779519742 @default.
• W2030590548 hasConceptScore W2030590548C2779969927 @default.
• W2030590548 hasConceptScore W2030590548C2780930700 @default.
• W2030590548 hasConceptScore W2030590548C2781197716 @default.
• W2030590548 hasConceptScore W2030590548C55493867 @default.
• W2030590548 hasConceptScore W2030590548C71924100 @default.
• W2030590548 hasConceptScore W2030590548C90924648 @default.

• next