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- W2030594039 endingPage "1250" @default.
- W2030594039 startingPage "1239" @default.
- W2030594039 abstract "Multipotent mesenchymal stromal or stem cells (MSCs) are likely to be agents of connective tissue homeostasis and repair. Because the hallmark of osteoarthritis (OA) is degeneration and failure to repair connective tissues it is compelling to think that these cells have a role to play in OA. Indeed, MSCs have been implicated in the pathogenesis of OA and, in turn, progression of the disease has been shown to be therapeutically modulated by MSCs. This review discusses current knowledge on the potential of both marrow- and local joint-derived MSCs in OA, the mode of action of the cells, and possible effects of the osteoarthritic niche on the function of MSCs. The use of stem cells for repair of isolated cartilage lesions and strategies for modulation of OA using local cell delivery are discussed as well as therapeutic options for the future to recruit and appropriately activate endogenous progenitors and/or locally systemically administered MSCs in the early stages of the disease. The use of gene therapy protocols, particularly as they pertain to modulation of inflammation associated with the osteoarthritic niche, offer an additional option in the treatment of this chronic disease. In summary, elucidation of the etiology of OA and development of technologies to detect early disease, allied to an increased understanding of the role MSCs in aging and OA, should lead to more targeted and efficacious treatments for this debilitating chronic disease in the future." @default.
- W2030594039 created "2016-06-24" @default.
- W2030594039 creator A5016505289 @default.
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- W2030594039 creator A5030012610 @default.
- W2030594039 creator A5067148319 @default.
- W2030594039 creator A5076064769 @default.
- W2030594039 date "2010-10-01" @default.
- W2030594039 modified "2023-10-10" @default.
- W2030594039 title "Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?" @default.
- W2030594039 cites W133078350 @default.
- W2030594039 cites W1487095330 @default.
- W2030594039 cites W1522229466 @default.
- W2030594039 cites W1607875640 @default.
- W2030594039 cites W1859919406 @default.
- W2030594039 cites W1963825794 @default.
- W2030594039 cites W1964752771 @default.
- W2030594039 cites W1966180610 @default.
- W2030594039 cites W1966767217 @default.
- W2030594039 cites W1966991920 @default.
- W2030594039 cites W1967869567 @default.
- W2030594039 cites W1968055329 @default.
- W2030594039 cites W1968746947 @default.
- W2030594039 cites W1969644104 @default.
- W2030594039 cites W1969772165 @default.
- W2030594039 cites W1970912767 @default.
- W2030594039 cites W1972461209 @default.
- W2030594039 cites W1973598383 @default.
- W2030594039 cites W1973863581 @default.
- W2030594039 cites W1976089856 @default.
- W2030594039 cites W1976960856 @default.
- W2030594039 cites W1977564820 @default.
- W2030594039 cites W1977897166 @default.
- W2030594039 cites W1978549824 @default.
- W2030594039 cites W1980397480 @default.
- W2030594039 cites W1982023994 @default.
- W2030594039 cites W1982280509 @default.
- W2030594039 cites W1983085571 @default.
- W2030594039 cites W1984732140 @default.
- W2030594039 cites W1984886004 @default.
- W2030594039 cites W1987081782 @default.
- W2030594039 cites W1987964693 @default.
- W2030594039 cites W1988005968 @default.
- W2030594039 cites W1988188434 @default.
- W2030594039 cites W1988274207 @default.
- W2030594039 cites W1990205367 @default.
- W2030594039 cites W1991565515 @default.
- W2030594039 cites W1992935708 @default.
- W2030594039 cites W1993789974 @default.
- W2030594039 cites W1993811760 @default.
- W2030594039 cites W1995122819 @default.
- W2030594039 cites W2000097208 @default.
- W2030594039 cites W2002222421 @default.
- W2030594039 cites W2006933991 @default.
- W2030594039 cites W2010913292 @default.
- W2030594039 cites W2011913681 @default.
- W2030594039 cites W2015409533 @default.
- W2030594039 cites W2016931709 @default.
- W2030594039 cites W2019429806 @default.
- W2030594039 cites W2020078448 @default.
- W2030594039 cites W2021164682 @default.
- W2030594039 cites W2021482268 @default.
- W2030594039 cites W2022346732 @default.
- W2030594039 cites W2023474734 @default.
- W2030594039 cites W2024115441 @default.
- W2030594039 cites W2024452130 @default.
- W2030594039 cites W2028255006 @default.
- W2030594039 cites W2028524664 @default.
- W2030594039 cites W2034659824 @default.
- W2030594039 cites W2034810146 @default.
- W2030594039 cites W2036452348 @default.
- W2030594039 cites W2036623896 @default.
- W2030594039 cites W2036839600 @default.
- W2030594039 cites W2039728399 @default.
- W2030594039 cites W2042975300 @default.
- W2030594039 cites W2044025778 @default.
- W2030594039 cites W2044685047 @default.
- W2030594039 cites W2045080708 @default.
- W2030594039 cites W2047562000 @default.
- W2030594039 cites W2049567191 @default.
- W2030594039 cites W2050974735 @default.
- W2030594039 cites W2058970953 @default.
- W2030594039 cites W2059742411 @default.
- W2030594039 cites W2059984620 @default.
- W2030594039 cites W2061418608 @default.
- W2030594039 cites W2066868344 @default.
- W2030594039 cites W2070435400 @default.
- W2030594039 cites W2072990456 @default.
- W2030594039 cites W2074624875 @default.
- W2030594039 cites W2076491580 @default.
- W2030594039 cites W2076865425 @default.
- W2030594039 cites W2077817242 @default.
- W2030594039 cites W2078489918 @default.
- W2030594039 cites W2079011939 @default.
- W2030594039 cites W2080432848 @default.
- W2030594039 cites W2084264548 @default.
- W2030594039 cites W2084610846 @default.
- W2030594039 cites W2085668932 @default.