FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030594518> ?p ?o ?g. }

• W2030594518 endingPage "e2050" @default.
• W2030594518 startingPage "e2050" @default.
• W2030594518 abstract "Chikungunya virus (CHIKV) is an arthropod-borne virus responsible for recent epidemics in the Asia Pacific regions. A customized gene expression microarray of 18,760 transcripts known to target Aedes mosquito genome was used to identify host genes that are differentially regulated during the infectious entry process of CHIKV infection on C6/36 mosquito cells. Several genes such as epsin I (EPN1), epidermal growth factor receptor pathway substrate 15 (EPS15) and Huntingtin interacting protein I (HIP1) were identified to be differentially expressed during CHIKV infection and known to be involved in clathrin-mediated endocytosis (CME). Transmission electron microscopy analyses further revealed the presence of CHIKV particles within invaginations of the plasma membrane, resembling clathrin-coated pits. Characterization of vesicles involved in the endocytic trafficking processes of CHIKV revealed the translocation of the virus particles to the early endosomes and subsequently to the late endosomes and lysosomes. Treatment with receptor-mediated endocytosis inhibitor, monodansylcadaverine and clathrin-associated drug inhibitors, chlorpromazine and dynasore inhibited CHIKV entry, whereas no inhibition was observed with caveolin-related drug inhibitors. Inhibition of CHIKV entry upon treatment with low-endosomal pH inhibitors indicated that low pH is essential for viral entry processes. CHIKV entry by clathrin-mediated endocytosis was validated via overexpression of a dominant-negative mutant of Eps15, in which infectious entry was reduced, while siRNA-based knockdown of genes associated with CME, low endosomal pH and RAB trafficking proteins exhibited significant levels of CHIKV inhibition. This study revealed, for the first time, that the infectious entry of CHIKV into mosquito cells is mediated by the clathrin-dependent endocytic pathway." @default.
• W2030594518 created "2016-06-24" @default.
• W2030594518 creator A5000444748 @default.
• W2030594518 creator A5036874691 @default.
• W2030594518 creator A5037227044 @default.
• W2030594518 creator A5042840718 @default.
• W2030594518 creator A5049629025 @default.
• W2030594518 creator A5061932539 @default.
• W2030594518 creator A5064691389 @default.
• W2030594518 creator A5065456794 @default.
• W2030594518 creator A5075360900 @default.
• W2030594518 creator A5082811377 @default.
• W2030594518 date "2013-02-07" @default.
• W2030594518 modified "2023-09-27" @default.
• W2030594518 title "Mosquito Cellular Factors and Functions in Mediating the Infectious entry of Chikungunya Virus" @default.
• W2030594518 cites W110006237 @default.
• W2030594518 cites W1552785739 @default.
• W2030594518 cites W1554156185 @default.
• W2030594518 cites W1564861448 @default.
• W2030594518 cites W1583085743 @default.
• W2030594518 cites W1679367724 @default.
• W2030594518 cites W1766564474 @default.
• W2030594518 cites W1835852057 @default.
• W2030594518 cites W1953625602 @default.
• W2030594518 cites W1964031657 @default.
• W2030594518 cites W1964339709 @default.
• W2030594518 cites W1981395994 @default.
• W2030594518 cites W1994940173 @default.
• W2030594518 cites W2000766338 @default.
• W2030594518 cites W2004960318 @default.
• W2030594518 cites W2007515183 @default.
• W2030594518 cites W2007614391 @default.
• W2030594518 cites W2008937064 @default.
• W2030594518 cites W2010409953 @default.
• W2030594518 cites W2010708749 @default.
• W2030594518 cites W2013274873 @default.
• W2030594518 cites W2015704490 @default.
• W2030594518 cites W2026677984 @default.
• W2030594518 cites W2028357619 @default.
• W2030594518 cites W2032554631 @default.
• W2030594518 cites W2034377840 @default.
• W2030594518 cites W2034747403 @default.
• W2030594518 cites W2035039373 @default.
• W2030594518 cites W2038122461 @default.
• W2030594518 cites W2043575852 @default.
• W2030594518 cites W2044191234 @default.
• W2030594518 cites W2046681916 @default.
• W2030594518 cites W2060544334 @default.
• W2030594518 cites W2060959687 @default.
• W2030594518 cites W2062504884 @default.
• W2030594518 cites W2069444054 @default.
• W2030594518 cites W2073204316 @default.
• W2030594518 cites W2078218183 @default.
• W2030594518 cites W2079350158 @default.
• W2030594518 cites W2081277267 @default.
• W2030594518 cites W2089541173 @default.
• W2030594518 cites W2089974427 @default.
• W2030594518 cites W2091001172 @default.
• W2030594518 cites W2091666608 @default.
• W2030594518 cites W2098659634 @default.
• W2030594518 cites W2101283856 @default.
• W2030594518 cites W2102265386 @default.
• W2030594518 cites W2109958551 @default.
• W2030594518 cites W2112032807 @default.
• W2030594518 cites W2114792084 @default.
• W2030594518 cites W2118016056 @default.
• W2030594518 cites W2121768774 @default.
• W2030594518 cites W2129436687 @default.
• W2030594518 cites W2132027627 @default.
• W2030594518 cites W2135388629 @default.
• W2030594518 cites W2136414528 @default.
• W2030594518 cites W2137750232 @default.
• W2030594518 cites W2138623102 @default.
• W2030594518 cites W2144115944 @default.
• W2030594518 cites W2145333947 @default.
• W2030594518 cites W2147268838 @default.
• W2030594518 cites W2150892563 @default.
• W2030594518 cites W2153052569 @default.
• W2030594518 cites W2160019429 @default.
• W2030594518 cites W2169424921 @default.
• W2030594518 cites W2616345050 @default.
• W2030594518 cites W4238726741 @default.
• W2030594518 cites W4243856904 @default.
• W2030594518 doi "https://doi.org/10.1371/journal.pntd.0002050" @default.
• W2030594518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3567007" @default.
• W2030594518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23409203" @default.
• W2030594518 hasPublicationYear "2013" @default.
• W2030594518 type Work @default.
• W2030594518 sameAs 2030594518 @default.
• W2030594518 citedByCount "55" @default.
• W2030594518 countsByYear W20305945182013 @default.
• W2030594518 countsByYear W20305945182014 @default.
• W2030594518 countsByYear W20305945182015 @default.
• W2030594518 countsByYear W20305945182016 @default.
• W2030594518 countsByYear W20305945182017 @default.
• W2030594518 countsByYear W20305945182018 @default.
• W2030594518 countsByYear W20305945182019 @default.
• W2030594518 countsByYear W20305945182020 @default.

• next