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- W2030594710 endingPage "3818" @default.
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- W2030594710 abstract "Considerable evidence has accumulated suggesting that the antigen receptor(s) on T cells is coded for by genes for the variable (V) region of the immunoglobulin heavy (H) chains. In B cells, a complete gene for the immunoglobulin VH region is formed by somatic recombination of VH and joining region heavy chain (JH) gene segments [through an intermediate diversity(D) region gene segment]. In an attempt to determine whether a complete immunoglobulin VH region is expressed on T cells that bear an antigen receptor, we analyzed the restriction map of the JH-C mu locus in genomic DNA from two cloned murine cytotoxic T-lymphocyte (CTL) lines specific for the x-ray-induced leukemia RL male 1. We found no rearrangement of the JH C mu locus in the CTL lines, indicating that the T-cell antigen receptor(s) in these CTLs is not coded for by a complete immunoglobulin VH gene formed by joining of VH, (DH), and JH genes. In addition, we determined that C mu genes on both chromosomes were present and that there was no rearrangement of the C alpha, C kappa, or lambda chain genes in these CTL cells." @default.
- W2030594710 created "2016-06-24" @default.
- W2030594710 creator A5000260833 @default.
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- W2030594710 date "1981-06-01" @default.
- W2030594710 modified "2023-09-24" @default.
- W2030594710 title "Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus." @default.
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- W2030594710 doi "https://doi.org/10.1073/pnas.78.6.3814" @default.
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