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- W2030600886 abstract "Abstract Introduction : The purpose of this study was to test the hypothesis that malignant hyperthermia model mice (RyR1Y522S/wt) are more vulnerable to exercise‐induced muscle injury and fatigability and adapt less to run training. Methods : After 6 weeks of voluntary wheel running, we measured anterior crural muscle fatigability, muscle injury, and cytochrome oxidase (COX) and citrate synthase (CS). Results : Although RyR1Y522S/wt mice ran without undergoing MH episodes, they ran 42% less distance than wild‐type (WT) mice. Muscles from WT mice exhibited increased fatigue resistance and COX content after training. Muscles from RyR1Y522S/wt mice demonstrated no significant change in fatigability or COX and CS after training. However, muscles from RyR1Y522S/wt mice displayed less intrinsic fatigability and greater COX/CS content and muscle damage than WT mice. Conclusions : RyR1Y522S/wt mice can run without having rhabdomyolysis, and their inability to adapt to training appears to stem from intrinsic enhancement of mitochondrial enzymes and fatigue resistance. Muscle Nerve, 2012" @default.
- W2030600886 created "2016-06-24" @default.
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- W2030600886 date "2012-03-16" @default.
- W2030600886 modified "2023-10-18" @default.
- W2030600886 title "Oxidative capacity and fatigability in run-trained malignant hyperthermia-susceptible mice" @default.
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- W2030600886 doi "https://doi.org/10.1002/mus.22343" @default.
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