Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030603455> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2030603455 endingPage "182" @default.
- W2030603455 startingPage "175" @default.
- W2030603455 abstract "Recent search revealed that nemo-like kinase (NLK) was identified as a negative regulator of the wingless type signal cascade in Xenopus and in Caenorhabditis elegans. NLK phosphorylates T-cell factor (TCF)/lymphoid enhancer-binding factor (LEF) and interferes with binding of the β-catenin-TCF/LEF complex to its TCF target site. After we constructed bacterial artificial chromosome clone contig covering more than 45-kb NLK chromosomal gene, genomic cloning revealed that the human NLK gene consists of 11 exons interrupted by ten introns; its translation-initiation site is within exon 1, and the termination codon and polyadenylation signal lie in exon 11. The 289 amino acids of its kinase domain extend from the 3′-portion of exon 1 to the 5′-portion of exon 9, and show a high degree of similarity in amino acid sequence to kinase domains of extracellular-signal regulated kinase 5 (mitogen activated protein kinase 7) and cyclin-dependent kinases, although the positions of introns among those genes are not conserved. Reverse transcription polymerase chain reactions analysis in various tissues showed that NLK is expressed ubiquitously. Analysis of its promoter region by luciferase reporter assays in transfected HeLa and NIH3T3 cells revealed that an upstream region from −487 to +33 bp of the NLK gene contains significant promoter activity. This 5′-flanking region probably contains the cis-acting element of NLK. In addition, our mutation screening showed that NLK was not a mutational target in breast and colorectal tumor cells." @default.
- W2030603455 created "2016-06-24" @default.
- W2030603455 creator A5000321427 @default.
- W2030603455 creator A5010309929 @default.
- W2030603455 creator A5017186518 @default.
- W2030603455 creator A5017928696 @default.
- W2030603455 creator A5047880957 @default.
- W2030603455 creator A5058063773 @default.
- W2030603455 creator A5088941541 @default.
- W2030603455 date "2002-02-01" @default.
- W2030603455 modified "2023-09-24" @default.
- W2030603455 title "Genomic structure of the human NLK (nemo-like kinase) gene and analysis of its promoter region" @default.
- W2030603455 cites W1498146886 @default.
- W2030603455 cites W1640296793 @default.
- W2030603455 cites W1902879109 @default.
- W2030603455 cites W1965051773 @default.
- W2030603455 cites W1984513595 @default.
- W2030603455 cites W1988787848 @default.
- W2030603455 cites W1998602132 @default.
- W2030603455 cites W1999112733 @default.
- W2030603455 cites W2002220979 @default.
- W2030603455 cites W2008228569 @default.
- W2030603455 cites W2015502095 @default.
- W2030603455 cites W2018658982 @default.
- W2030603455 cites W2045183751 @default.
- W2030603455 cites W2049869441 @default.
- W2030603455 cites W2069146068 @default.
- W2030603455 cites W2081550264 @default.
- W2030603455 cites W2085745426 @default.
- W2030603455 cites W2146167376 @default.
- W2030603455 cites W2148074532 @default.
- W2030603455 cites W2167109216 @default.
- W2030603455 cites W2033233906 @default.
- W2030603455 doi "https://doi.org/10.1016/s0378-1119(02)00412-2" @default.
- W2030603455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12039044" @default.
- W2030603455 hasPublicationYear "2002" @default.
- W2030603455 type Work @default.
- W2030603455 sameAs 2030603455 @default.
- W2030603455 citedByCount "13" @default.
- W2030603455 countsByYear W20306034552013 @default.
- W2030603455 countsByYear W20306034552014 @default.
- W2030603455 countsByYear W20306034552016 @default.
- W2030603455 crossrefType "journal-article" @default.
- W2030603455 hasAuthorship W2030603455A5000321427 @default.
- W2030603455 hasAuthorship W2030603455A5010309929 @default.
- W2030603455 hasAuthorship W2030603455A5017186518 @default.
- W2030603455 hasAuthorship W2030603455A5017928696 @default.
- W2030603455 hasAuthorship W2030603455A5047880957 @default.
- W2030603455 hasAuthorship W2030603455A5058063773 @default.
- W2030603455 hasAuthorship W2030603455A5088941541 @default.
- W2030603455 hasConcept C101762097 @default.
- W2030603455 hasConcept C104317684 @default.
- W2030603455 hasConcept C111936080 @default.
- W2030603455 hasConcept C150194340 @default.
- W2030603455 hasConcept C153911025 @default.
- W2030603455 hasConcept C36823959 @default.
- W2030603455 hasConcept C54355233 @default.
- W2030603455 hasConcept C86339819 @default.
- W2030603455 hasConcept C86803240 @default.
- W2030603455 hasConcept C94671646 @default.
- W2030603455 hasConceptScore W2030603455C101762097 @default.
- W2030603455 hasConceptScore W2030603455C104317684 @default.
- W2030603455 hasConceptScore W2030603455C111936080 @default.
- W2030603455 hasConceptScore W2030603455C150194340 @default.
- W2030603455 hasConceptScore W2030603455C153911025 @default.
- W2030603455 hasConceptScore W2030603455C36823959 @default.
- W2030603455 hasConceptScore W2030603455C54355233 @default.
- W2030603455 hasConceptScore W2030603455C86339819 @default.
- W2030603455 hasConceptScore W2030603455C86803240 @default.
- W2030603455 hasConceptScore W2030603455C94671646 @default.
- W2030603455 hasFunder F4320320912 @default.
- W2030603455 hasFunder F4320321945 @default.
- W2030603455 hasFunder F4320334764 @default.
- W2030603455 hasIssue "1-2" @default.
- W2030603455 hasLocation W20306034551 @default.
- W2030603455 hasLocation W20306034552 @default.
- W2030603455 hasOpenAccess W2030603455 @default.
- W2030603455 hasPrimaryLocation W20306034551 @default.
- W2030603455 hasRelatedWork W1999232590 @default.
- W2030603455 hasRelatedWork W2037918956 @default.
- W2030603455 hasRelatedWork W2039352533 @default.
- W2030603455 hasRelatedWork W2051065561 @default.
- W2030603455 hasRelatedWork W2059736436 @default.
- W2030603455 hasRelatedWork W2072834586 @default.
- W2030603455 hasRelatedWork W2085975240 @default.
- W2030603455 hasRelatedWork W2092554027 @default.
- W2030603455 hasRelatedWork W2418488235 @default.
- W2030603455 hasRelatedWork W4242521457 @default.
- W2030603455 hasVolume "285" @default.
- W2030603455 isParatext "false" @default.
- W2030603455 isRetracted "false" @default.
- W2030603455 magId "2030603455" @default.
- W2030603455 workType "article" @default.