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• W2030605439 endingPage "9530" @default.
• W2030605439 startingPage "9521" @default.
• W2030605439 abstract "Using whole-cell patch-clamp methods, we examined the hypothesis that serotonin [5-hydroxytryptamine (5-HT)] receptor activation enhances TRPV1 function in mouse colon sensory neurons in lumbosacral dorsal root ganglia, which were identified by retrograde labeling with DiI (1,1′-dioctadecyl-3,3,3′,3-tetramethlindocarbocyanine methanesulfonate) injected into multiple sites in the wall of the descending colon. 5-HT increased membrane excitability at a temperature below body temperature in response to thermal ramp stimuli in colon sensory neurons from wild-type mice, but not from TRPV1 knock-out mice. 5-HT significantly enhanced capsaicin-, heat-, and proton-evoked currents with an EC 50 value of 2.2 μ m . 5-HT (1 μ m ) significantly increased capsaicin-evoked (100 n m ) and proton-evoked (pH 5.5) currents 1.6- and 4.7-fold, respectively, and significantly decreased the threshold temperature for heat current activation from 42 to 38°C. The enhancement of TRPV1 by 5-HT was significantly attenuated by selective 5-HT 2 and 5-HT 4 receptor antagonists, but not by a 5-HT 3 receptor antagonist. In support, 5-HT 2 and 5-HT 4 receptor agonists mimicked the facilitating effects of 5-HT on TRPV1 function. Downstream signaling required G-protein activation and phosphorylation as intracellularly administered GDP-β-S [guanosine 5′- O -(2-thiodiphosphate], protein kinase A inhibitors, and an A-kinase anchoring protein inhibitor significantly blocked serotonergic facilitation of TRPV1 function; 5-HT 2 receptor-mediated facilitation was also inhibited by a PKC inhibitor. We conclude that the facilitation of TRPV1 by metabotropic 5-HT receptor activation may contribute to hypersensitivity of primary afferent neurons in irritable bowel syndrome patients." @default.
• W2030605439 created "2016-06-24" @default.
• W2030605439 creator A5027305249 @default.
• W2030605439 creator A5047147039 @default.
• W2030605439 creator A5047846623 @default.
• W2030605439 date "2004-10-27" @default.
• W2030605439 modified "2023-10-11" @default.
• W2030605439 title "TRPV1 Function in Mouse Colon Sensory Neurons Is Enhanced by Metabotropic 5-Hydroxytryptamine Receptor Activation" @default.
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• W2030605439 doi "https://doi.org/10.1523/jneurosci.2639-04.2004" @default.
• W2030605439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6730150" @default.
• W2030605439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15509739" @default.
• W2030605439 hasPublicationYear "2004" @default.
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